Evidence map›Paper›PMID 41749888›Full record

ArticleCancers2026

Racial and Ethnic Disparities in Second Primary Lung Cancer After Breast Radiotherapy: A SEER Cohort Analysis (2000-2022).

Fares A Qtaishat, Mohammad Hamad, Adham Musa, Theeb Natsheh, Othman Al-Barghouthi, Basil A Abusalameh, Anas A Younis, Hamzeh Al-Qarallah, Sara Qutaishat, Matthew P Banegas and 3 more

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In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fares A QtaishatSchool of Medicine, University of Jordan, Amman 11942, Jordan.ORCID 0009-0005-6017-2861
Mohammad HamadSchool of Medicine, University of Jordan, Amman 11942, Jordan.
Adham MusaCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0006-6331-0040
Theeb NatshehFaculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0009-0000-8985-9011
Othman Al-BarghouthiFaculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0009-0008-7640-4964
Basil A AbusalamehSchool of Medicine, University of Jordan, Amman 11942, Jordan.ORCID 0009-0001-4836-6007
Anas A YounisSchool of Medicine, University of Jordan, Amman 11942, Jordan.
Hamzeh Al-QarallahSchool of Medicine, University of Jordan, Amman 11942, Jordan.
Sara QutaishatDepartment of Internal Medicine, Medstar Union Memorial Hospital, Baltimore, MD 21218, USA.
Matthew P BanegasDepartment of Radiation Medicine and Applied Sciences, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
H Irene SuDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6671-5151
Winta T MehtsunDivision of Surgical Oncology, Department of Surgery, UC San Diego School of Medicine, La Jolla, CA 92093, USA.
Tala Al-RousanHerbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8274-924X

Funding

National Heart, Lung and Blood Institute R01HL173155National Intsitue of Aging #P30AG059299
6 · The paper itself

Abstract

backgroundAdjuvant radiation therapy for breast cancer improves survival but may expose thoracic organs to low-dose radiation, increasing the risk of second primary lung cancer (SPLC). Racial and ethnic disparities and social factors influencing SPLC risk remain underexplored.

objectivesWe quantified racial and ethnic differences in SPLC incidence and survival among radiotherapy-treated breast cancer survivors and assessed the potential protective role of marital status.

methodsUsing SEER-17 (2000-2022), we identified patients with first primary breast cancer receiving radiotherapy, excluding those who died within two months. Standardized incidence ratios (SIRs) assessed observed versus expected SPLC cases by race and ethnicity and marital status, and five-year overall survival (OS) after SPLC and mean age at death were calculated. Racial categories included White, Black, Asian or Pacific Islander (API), and American Indian or Alaska Native (AI/AN); ethnicity was categorized as Hispanic or non-Hispanic.

resultsAmong 558,493 patients, 6674 developed SPLC (1.19%). Risk varied significantly by race (

conclusionsSPLC risk and prognosis after breast radiotherapy differ by race, ethnicity, and marital status. These findings highlight the importance of context-aware survivorship counseling and support the consideration of personalized lung cancer screening for breast cancer survivors.

Indexed as

adjuvant radiotherapybreast cancercancer survivorshipethnic disparitieshealth disparitiesmarital statusracial disparitiessecond primary lung cancerSEER databasesurvival outcomes

Identifiers

PMID41749888
PMCPMC12939512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.