Evidence map›Paper›PMID 41749844›Full record

ArticleCancers2026

Endoscopic One-Nostril Transseptal Transsphenoidal Approach for Pituitary Tumors: Back to the Past-A Multi-Center Preliminary Experience and Literature Review.

Denis Aiudi, Alessio Iacoangeli, Andrea Mattioli, Simone Russo, Massimo Balbi, Stefano Vecchioni, Michele Luzi, Roberto Trignani, Alberto Califano, Ruggero Antonini and 6 more

Abstract read
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In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Denis AiudiNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.ORCID 0000-0001-9293-5185
Alessio IacoangeliNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.ORCID 0000-0003-4514-0704
Andrea MattioliNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Simone RussoDepartment of Otolaryngology, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Massimo BalbiDepartment of Otolaryngology, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Stefano VecchioniDivision of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.ORCID 0009-0004-7074-8054
Michele LuziDivision of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Roberto TrignaniDivision of Neurosurgery, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Alberto CalifanoNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Ruggero AntoniniNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Mario ChiapponiNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Fabio GrecoDepartment of Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 00128 Roma, Italy.
Fabrizio SalvinelliDepartment of Otolaryngology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 00128 Roma, Italy.
Kenan ArnautovicSemmes Murphey Neurologic & Spine Institute, Memphis, TN 38120, USA.
Maurizio IacoangeliNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Maurizio GladiNeurosurgical Department, Marche Polytechnic University, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEndoscopic endonasal transsphenoidal pituitary surgery is a diffuse and well-established surgical technique: over the years, the transseptal approach via a nasal mucosal incision has also gained popularity. Here we describe our preliminary experience with an entirely endoscopic one-nostril transseptal transsphenoidal approach (EONOTTA) for pituitary sellar tumor resection; the surgical corridor runs through the entire length of the nasal septum via an incision in the nasal mucosa.

methodsA total of 40 patients with a midline prevalent pituitary tumor who underwent EONOTTA from January 2022 to June 2023 were retrospectively reviewed for the evaluation of the safety and efficacy of this technique.

resultsAt 1 year follow-up, all patients had no recurrence, and the degree of tumor resection was comparable to that of the control group undergoing the traditional endoscopic endonasal approach. A low rate of nasal and post-surgical complications occurred; globally, EONOTTA was not time-consuming, and a better functional result was noticed, with a better quality of life for patients.

conclusionsThis study confirms, in our preliminary experience, the EONOTTA's excellent risk-benefit ratio in selected cases; for an experienced multidisciplinary team, it provides a good maneuverability and a functional outcome while preserving the integrity of the nasal mucosa.

Indexed as

endoscopicmono-nostrilpituitary tumortransseptaltranssphenoidal

Identifiers

PMID41749844
PMCPMC12939709

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.