Evidence map›Paper›PMID 41749799›Full record

ReviewCancers2026

The Impact of the Number of Neoadjuvant Chemotherapy Cycles on Outcomes in Advanced Ovarian Cancer: A Narrative Review.

Ana Carla Franco Ubinha, Camila Musa Honorato, Marcelo Henrique Dos Santos, Luis Pires de Melo Filho, Luciano Ipólito Branquinho, Adhemar Longatto-Filho, Ricardo Dos Reis

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Carla Franco UbinhaDepartment of Gynecologic Oncology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.
Camila Musa HonoratoBarretos School of Health Sciences, Dr. Paulo Prata-FACISB, Barretos 14785-002, Brazil.
Marcelo Henrique Dos SantosDepartment of Gynecologic Oncology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.
Luis Pires de Melo FilhoDepartment of Gynecologic Oncology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.ORCID 0000-0002-7457-0677
Luciano Ipólito BranquinhoDepartment of Gynecologic Oncology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.ORCID 0000-0001-9272-8397
Adhemar Longatto-FilhoMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, Brazil.ORCID 0000-0002-5779-9752
Ricardo Dos ReisDepartment of Gynecologic Oncology, Barretos Cancer Hospital, Barretos 14784-400, Brazil.ORCID 0000-0002-8271-3690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although standard chemotherapy for three to four cycles followed by surgery is considered safe and effective in the management of advanced ovarian cancer, the impact of extending treatment beyond this period remains uncertain. Some authors suggest that the number of neoadjuvant chemotherapy cycles does not directly affect prognosis and may reflect a confounding bias. Others, however, indicate that a prolonged exposure to chemotherapy can promote the selection of resistant tumor clones, negatively influencing patient survival and disease progression. This review aims to summarize the current evidence on the topic, evaluating the effect of prolonged chemotherapy on surgical cytoreduction and survival. To achieve this, we conducted an analysis of the English-language literature available in PubMed, focusing on treatment duration, achievement of complete surgical resection, survival outcomes, and prognostic factors.

Indexed as

cytoreduction surgeryinterval debulking surgeryneoadjuvant chemotherapyovarian cancer

Identifiers

PMID41749799
PMCPMC12938755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.