Evidence map›Paper›PMID 41749776›Full record

ArticleBioengineering (Basel, Switzerland)2026

A Multiscale Evaluation of Erbium-Doped Yttrium-Aluminum-Garnet Laser Osteotomy: Integrating Macroscopic and Cellular Analyses.

Anjie Shen, Boxuan Huang, Hang Bao, Teng Zhang, Kaijun Zhang, Bin Zhao, Haoyuan Du, Junqiang Wang, Wei Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anjie ShenDepartment of Orthopedic Trauma, Peking University Fourth School of Clinical Medicine, Peking University, Beijing 100035, China.
Boxuan HuangDepartment of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Hang BaoDepartment of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Teng ZhangDepartment of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Kaijun ZhangDepartment of Orthopedic Trauma, Peking University Fourth School of Clinical Medicine, Peking University, Beijing 100035, China.
Bin ZhaoDepartment of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Haoyuan DuDepartment of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Junqiang WangDepartment of Orthopedic Trauma, Peking University Fourth School of Clinical Medicine, Peking University, Beijing 100035, China.
Wei HanDepartment of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.

Funding

Beijing Natural Science Foundation L222011National Key Research and Development Program of China 2024YFB3613303
6 · The paper itself

Abstract

backgroundTraditional high-speed mechanical osteotomes cause substantial thermal and mechanical trauma, impairing bone healing. Erbium-doped yttrium-aluminum-garnet (Er:YAG) lasers, with water-mediated non-contact ablation, offer precise osteotomy potential with minimal collateral damage. This study demonstrated the feasibility of Er:YAG laser use for complex osteotomies and elucidated its multi-scale biological impacts on bone.

methodsA custom Er:YAG laser performed Z/arc-shaped osteotomies on fresh ovine bone (oscillating saw as control); paired rat tibial osteotomies; and compared laser vs. saw resection. Osteotomy surfaces were characterized by SEM/micro-CT; histological staining quantified thermal/mechanical damage. Bone marrow-derived mesenchymal stem cell (BMSC) adhesion, viability, and infiltration on cut surfaces were evaluated via LSCM.

resultIn the ex vivo ovine model, the Er:YAG laser enabled precise execution of complex osteotomies (Z-shaped and arc-shaped), producing significantly narrower gaps than the oscillating saw (1.14 mm vs. 2.70 mm,

conclusionsIn conclusion, this proof-of-concept study demonstrates that the Er:YAG laser has the potential to enable precise bone resection while preserving microstructure. By establishing a pro-regenerative microenvironment, this technology shows promise as a biologically favorable alternative to conventional sawing, although further technical refinement and long-term validation are essential for its clinical translation.

Indexed as

bone healinglaser bone surgerynon-contact ablationorthopedic surgeryprecision osteotomy

Identifiers

PMID41749776
PMCPMC12938275

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.