Evidence map›Paper›PMID 41749728›Full record

ArticleBioengineering (Basel, Switzerland)2026

A Novel, Low-Cost, 3D-Printed Motorized Injector for Retinal Sheet Transplantation.

Jerald Lim, Francis Ung, Samir Malhotra, Jacob C Diaz, Austen Hamilton, Clare Chen, William C Tang, Magdalene J Seiler, Andrew W Browne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jerald LimSchool of Medicine, University of California Irvine, Irvine, CA 92697, USA.ORCID 0009-0009-6029-733X
Francis UngDepartment of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA.ORCID 0009-0001-9172-7656
Samir MalhotraDepartment of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8542-0335
Jacob C DiazDepartment of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA.ORCID 0009-0004-9716-8017
Austen HamiltonBrunson Center for Translational Vision Research, University of California Irvine, Irvine, CA 92697, USA.
Clare ChenDepartment of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA.
William C TangGavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-4183-520X
Magdalene J SeilerDepartment of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-0869-9923
Andrew W BrowneDepartment of Ophthalmology and Visual Sciences, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-5351-461X

Funding

NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI James V Jester · 2022 to 2026
$3.7M
Integration and functionality of retinal organoid transplantsR01EY031834 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEILER, MAGDALENE J · 2021 to 2025
$3.0M
In vivo 2-photon imaging of retinal biochemistry before and after retinal organoid transplantationK08EY034912 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BROWNE, ANDREW W · 2023 to 2025
$583k
NEI NIH HHS K08 EY034912NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY031834NIH HHS 1K08EY034912-01NIH HHS 5P30EY034070-03NIH HHS 5R01EY031834-03NIH HHS 5R01EY032948-02
6 · The paper itself

Abstract

Retinal transplantation offers promise for restoring vision in advanced retinal degeneration. However, manual delivery of retinal sheets is often hindered by imprecise placement and collateral tissue damage resulting from instrument instability. We introduce a novel, 3D-printed, motorized retinal sheet injector designed to enhance placement accuracy and minimize tissue injury. The motorized injector features an Arduino-controlled foot pedal with three discrete actuator positions ("Min", "Mid", "Max"). When compared via frame-by-frame motion analysis, the motorized system reduced tip variance by approximately threefold over manual methods. In addition, in in vitro gelatin trials, the motorized injector achieved significantly higher placement accuracy versus the manual injector, which suffered from occasional complete misplacements. The novel motorized retinal sheet injector markedly improves stability and placement accuracy relative to manual methods, potentially reducing complications associated with subretinal delivery. Safer subretinal delivery can pave the way for innovative research and advanced treatment for retinal disease.

Indexed as

3D printinstrumentorganoidretinatransplant

Identifiers

PMID41749728
PMCPMC12937642

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.