Evidence map›Paper›PMID 41749653›Full record

ArticleChildren (Basel, Switzerland)2026

Occlusal Relationships and Dental Changes in Mixed Dentition Patients Treated with Clear Aligners: A 2-Year Follow Up.

Francesca Gazzani, Chiara Pavoni, Francesca Chiara De Razza, Letizia Lugli, Saveria Loberto, Alessio Lachi, Paola Cozza, Roberta Lione

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Francesca GazzaniDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.
Chiara PavoniDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.ORCID 0000-0001-6720-1606
Francesca Chiara De RazzaDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.
Letizia LugliDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.
Saveria LobertoDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.
Alessio LachiDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.ORCID 0000-0002-0764-0866
Paola CozzaDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.
Roberta LioneDepartment of Health Science, UniCamillus-Saint Camillus International Medical University, 00131 Rome, Italy.ORCID 0000-0001-9292-3248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study assessed the long-term stability of dental arch changes achieved through clear aligner treatment in growing patients during the early mixed dentition stage.

methodsThis retrospective study included 20 patients (mean age 8.3 ± 0.4 years) treated with clear aligners according to a standardized sequential expansion protocol. No additional auxiliaries, interproximal reductions, or retentions were used. Dental casts were collected at baseline (T0), end of treatment (T1), and two years post-treatment without retention (T2). Linear and angular measurements (arch width, molar and incisor torque, Henry's angle, overjet, overbite, and Little's index) were assessed on digital models. Friedman ANOVA and Wilcoxon signed-rank tests were applied (α = 0.05).

resultsAt T1-T0, significant transversal expansion was achieved in both arches (U6-6 mesial +2.1 mm; L6-6 mesial +2.4 mm;

conclusionsClear aligners in early mixed dentition achieved significant and stable dental arch modifications over a 2-year follow-up without the use of retention appliances. This therapeutic approach may represent a reliable interceptive option in growing patients.

Indexed as

arch expansionclear alignersinterceptive orthodonticslong-term stabilitymixed dentition

Identifiers

PMID41749653
PMCPMC12939305

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