Utilizing the Lactate Dehydrogenase-to-Albumin Ratio for Survival Prediction in Patients with Neuroblastoma.

Suwen Li, Yue Ma, Shan Wang

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Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Suwen LiDepartment of Oncological Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.ORCID 0000-0001-7567-071X

Yue MaDepartment of Oncological Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.

Shan WangDepartment of Oncological Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.

Funding

the Key Project of Research on Prevention and Control of Major Chronic Non-Communicable Diseases, the Ministry of Science and Technology of the People's Republic of China, National Key R&D Program of China (2018YFC1313000, 2018YFC1313004).

6 · The paper itself

Abstract

purposeThis study aimed to investigate the association between lactate dehydrogenase-to-albumin ratio (LAR) and the clinical characteristics and overall survival (OS) of patients with neuroblastoma (NB).

methodsWe conducted a retrospective data analysis of 443 patients diagnosed with neuroblastoma. The optimal cut-off value for the LAR was determined using receiver operating characteristic (ROC) curves. We utilized Kaplan-Meier curves and Cox regression analysis to evaluate the relationship between LAR and OS. Independent factors identified through multivariate analysis were employed to construct a nomogram. The performance of the nomogram model was assessed using calibration curves, ROC curves, concordance index (C-index), and decision curve analysis (DCA).

resultsThe 2-year time-dependent ROC curve indicated that the optimal cut-off value for the LAR was 21.814. Kaplan-Meier survival curve analysis revealed that the prognosis for the high LAR group was significantly worse than that for the low LAR group. Results from multivariate Cox analysis identified INSS stage, bone metastasis,

conclusionsLAR served as an aussichtsreich prognostic indicator for neuroblastoma, and the nomogram model based on LAR can predict the OS of patients with this condition.

Indexed as

albuminlactate dehydrogenaselactate dehydrogenase-to-albumin rationeuroblastomaprognosis

Identifiers

PMID41749576

DOI10.3390/children13020220

PMCPMC12940032

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