Evidence map›Paper›PMID 41749525›Full record

ReviewChildren (Basel, Switzerland)2026

The Cross-Knit Between Immune Cells and Thyroid Function in Autoimmune Thyroid Disorders: What We Can Learn from Inborn Errors of Immunity.

Laura Grilli, Francesca Cillo, Roberta Romano, Giuliana Giardino, Francesca Romana Rotondo, Sara Vasaturo, Mariacarolina Salerno, Donatella Capalbo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura GrilliPediatric Immunology Unit, Department of Translational Medical Sciences, University of Naples Federico II, 80138 Naples, Italy.
Francesca CilloPediatric Immunology Unit, Department of Translational Medical Sciences, University of Naples Federico II, 80138 Naples, Italy.
Roberta RomanoDepartment of Mother and Child, University Hospital Federico II, ERN-RITA Center for Rare Immundeficiencies, 80138 Naples, Italy.
Giuliana GiardinoPediatric Immunology Unit, Department of Translational Medical Sciences, University of Naples Federico II, 80138 Naples, Italy.
Francesca Romana RotondoDepartment of Mother and Child, University Hospital Federico II, Endo-ERN Center for Rare Endocrine Conditions, 80138 Naples, Italy.
Sara VasaturoDepartment of Mother and Child, University Hospital Federico II, Endo-ERN Center for Rare Endocrine Conditions, 80138 Naples, Italy.
Mariacarolina SalernoDepartment of Mother and Child, University Hospital Federico II, Endo-ERN Center for Rare Endocrine Conditions, 80138 Naples, Italy.ORCID 0000-0003-1310-3300
Donatella CapalboDepartment of Mother and Child, University Hospital Federico II, Endo-ERN Center for Rare Endocrine Conditions, 80138 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune thyroid diseases (AITDs), including Hashimoto thyroiditis and Graves' disease, are the most common autoimmune endocrinopathies, affecting up to 5% of the population. Pathogenetic pathways have not yet been fully elucidated, even though different immune-genetic alterations have been proposed. Specific immune defects presenting with AITDs may serve as an experimentum naturae to study the involvement of a specific pathway in the pathogenesis of the disease. In fact, since immune dysregulation with autoimmunity frequently characterize inborn errors of immunity (IEIs), understanding the mechanisms of immune tolerance breakdown leading to autoimmunity in these conditions may provide useful insight to understand the pathogenesis of AITDs. In this review, we will highlight the main immunological aspects of AITDs and their pathogenesis in IEIs.

Indexed as

autoimmune thyroid diseasesimmunodysregulationinborn errors of immunity

Identifiers

PMID41749525
PMCPMC12939510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.