ArticleJournal of applied toxicology : JAT2026
Assessment of Gold-Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement.
Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti-inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the biological effects of gold in animal models and humans. In the present study, we explored the impacts of a gold solution, used in chrysotherapy, on the reproductive function of male Wistar rats. Seven chronic intraperitoneal injections of sodium 3-aurothio-2-hydroxypropane-1-sulfonate at 30% of gold (allochrysine) were administered to adult male Wistar rats over a period of 2 weeks. The control rats received 0.9% NaCl solution. Our results showed that gold has no notable effect on the absolute weight of reproductive organs (testicles, epididymides, seminal vesicles, and the two caudae of the epididymides) and of nonreproductive organs (liver and brain) excepting the kidneys. The assessment of the fertility parameters showed a significant decline in the motility and viability of sperm cells. A slight reduction in the sperm density, and many malformations affecting the spermatozoa were detected, and the testosterone levels in rats' blood were also significantly diminished. Our study showed that administration of gold solution reduced sperm parameters and was a disruptive agent for the endocrine function of testicles. The oxidative stress generation, attributed to this heavy metal, led to a significant hypertrophy of the kidneys probably after inflammation. Thus, gold existing in different medical treatments could be classified as an endocrine disruptor and could be a detrimental factor of male fertility.
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