Evidence map›Paper›PMID 41749377›Full record

ReviewOral diseases2026

A Review on Image Processing and Fractal Analysis in Oral Potentially Malignant Disorders.

André Goulart Poletto, Flaviana Silva de Souza, Lilian Bezerra, Thiago Pires Claudio, Jesse Parente Tocantins, Helena Miguel Cotter, Riéli Elis Schulz, Karin Berria Tomazelli, Elena Riet Correa Rivero, Fabio Luiz Coracin and 1 more

Abstract readReview
In one paragraph

Review in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

André Goulart PolettoDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0002-3827-052X
Flaviana Silva de SouzaDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0009-0000-2036-3579
Lilian BezerraDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0009-0005-8098-2781
Thiago Pires ClaudioDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0002-1437-8720
Jesse Parente TocantinsDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0009-0001-0606-5601
Helena Miguel CotterDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0001-7613-3465
Riéli Elis SchulzDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0001-6357-0092
Karin Berria TomazelliDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0001-7395-6597
Elena Riet Correa RiveroDepartment of Pathology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0002-8516-8771
Fabio Luiz CoracinDepartment of Dentistry and Pathology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0108-6593
Gustavo Davi RabeloDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID https://orcid.org/0000-0001-9511-5078

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 403656/2021-4Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
6 · The paper itself

Abstract

aimThe clinical evaluation of patients with oral potentially malignant disorders is primarily based on physical examination and observable clinical features. Clinical photographs play a key role in patient monitoring and help identify signs that may indicate malignant transformation. These images can be accessed by artificial intelligence techniques and fractal analysis, and image processing and segmentation are crucial for these tasks. This review discusses image processing techniques applied to clinical photographs of oral potentially malignant disorders, with emphasis on fractal analysis.

methodsStudies investigating fractal dimension and lacunarity as measures of lesion complexity and homogeneity were reviewed, along with research on segmentation and binarization.

resultsA search of scientific databases identified 10 studies reporting the access of texture parameters on clinical images to measure fractal dimension and lacunarity.

conclusionsThe reviewed studies showed that fractal dimension and texture parameters were useful for evaluating lesions and distinguishing normal and pathological tissues; however, there is a lack of methodological standardization. Although fractal dimension was assessed in all articles, lacunarity was examined in just one. Binarization and segmentation impact fractal dimension, lacunarity, and other texture measurements, which can be significantly enhanced by appropriate image processing. In contrast, poorly executed preprocessing may lead to misinterpretation of results.

Indexed as

FractalsImage Processing, Computer-AssistedMouth NeoplasmsPrecancerous ConditionsArtificial IntelligenceHumansPhotographyartificial intelligencecomputer vision systemsintraoral photographyleukoplakiaoral cancer

Identifiers

PMID41749377
PMCPMC13590900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.