ArticleTrials2026
Using web-based CBT-I to improve sleep to prevent depression and anxiety in adolescents at high risk: a randomized controlled trial protocol.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06358495 (Improving Sleep to Prevent Depression & Anxiety in Adolescents at High Risk), which is not on this map. Not yet cited in PubMed.
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Improving Sleep to Prevent Depression & Anxiety in Adolescents at High Risk
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0 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong adolescents, internalizing disorders are a leading cause of the global burden of disability and death due to suicide. There is a critical need to prevent first-lifetime onsets of internalizing disorders, particularly among high-risk adolescents. Insomnia and poor sleep have been robustly linked to internalizing disorders in adolescents. The present trial will examine if brief, web-based Cognitive Behavioral Therapy for Insomnia (CBT-I) reduces insomnia symptoms, improves sleep quality, and improves subthreshold internalizing symptoms in never-clinically depressed or anxious adolescents with sleep problems (insomnia severity scores indicating subthreshold insomnia or higher) who are at risk for internalizing disorders due to a parental history of these disorders.
methodsThis trial uses a two-arm, single-blinded, parallel group randomized controlled design (N = 50). Participants in the treatment group will complete a web-based CBT-I intervention (return2sleep) that is comprised of 7 sessions (six adolescent sessions and one parent session). Participants in the control group will receive a psychoeducational pamphlet and be encouraged to continue treatment (if any) as usual. Insomnia severity, sleep quality, and depressive and anxiety symptoms will be assessed at three time points (baseline, immediately post-treatment, and three months post-treatment). Additionally, clinically significant internalizing disorders in adolescents will be assessed using diagnostic interviews. DISCUSSION: Web-based CBT-I is a non-invasive, economical, and easily administered intervention targeting sleep which is a potentially modifiable risk factor for the onset of depression and anxiety. Results from this trial will inform larger-scale effectiveness trials to examine whether, via interventions to improve sleep, it is possible to prevent currently healthy, but high-risk, adolescents with sleep problems from developing internalizing disorders for the first time in their lives, thereby preventing a lifelong cascade of adverse psychosocial outcomes.
trial registrationClinicalTrials.gov NCT06358495 . Registered on April 15, 2024.
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