Evidence map›Paper›PMID 41749274›Full record

ArticleImplementation science : IS2026

Implementation of optimized kangaroo care for infection prevention and control in neonatal intensive care units (NeoIPC): Protocol for the implementation elements of a multicenter parallel cluster randomized hybrid type 2 implementation-effectiveness study.

Marie-Therese Schultes, Julia Baenziger, Emanuela Nyantakyi, Cassie Xueqi Wu, Giovanfrancesco Ferrari, Elske Sieswerda, C Henri van Werkhoven, Chiara Minotti, Aline Wolfensberger, Fabrizio Tediosi and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Implementation science : IS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05993442 (Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in Neonatal Intensive Care), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05993442 narecruitingnot on this map

Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in Neonatal Intensive Care: a Pragmatic, Multicentre, Parallel Cluster Randomised Hybrid Implementation-effectiveness Study.

TypeinterventionalSponsorPENTA FoundationRan2024 to 2026Enrolled3,080ConditionsInfection, Bacterial, Infection PreventionArmsOptimised kangaroo care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marie-Therese Schultes *Institute for Implementation Science in Health Care, University of Zurich, Zurich, Switzerland.
Julia Baenziger *Institute for Implementation Science in Health Care, University of Zurich, Zurich, Switzerland.
Emanuela NyantakyiInstitute for Implementation Science in Health Care, University of Zurich, Zurich, Switzerland.
Cassie Xueqi WuInstitute for Implementation Science in Health Care, University of Zurich, Zurich, Switzerland.
Giovanfrancesco FerrariSwiss Tropical and Public Health Institute, Basel, Switzerland.
Elske SieswerdaJulius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
C Henri van WerkhovenJulius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Chiara MinottiDepartment of Clinical Research, Faculty of Medicine, University of Basel, Basel, Switzerland.
Aline WolfensbergerInstitute for Implementation Science in Health Care, University of Zurich, Zurich, Switzerland.
Fabrizio TediosiSwiss Tropical and Public Health Institute, Basel, Switzerland.
Federica D'AmbrosioFondazione Penta ETS, Padua, Italy.
Julia A BielickiDepartment of Clinical Research, Faculty of Medicine, University of Basel, Basel, Switzerland.
Lauren ClackInstitute for Implementation Science in Health Care, University of Zurich, Zurich, Switzerland. lauren.clack@uzh.ch.
NeoIPC Consortium

Funding

European Union's Horizon 2020 research and innovation programme 965328
6 · The paper itself

Abstract

backgroundHospital-acquired neonatal severe infections and resistant bacterial colonization in neonatal care are a world-wide challenge. Preventing the spread of resistant bacteria in neonatal intensive care units (NICUs) is specifically challenging, for example, due to multi-patient rooms, spaces being crowded with equipment, and high antibiotic use in these settings. Kangaroo care (KC), a practice that involves skin-to-skin contact between newborn infants and caregivers, is a promising, low-cost intervention that has been associated with reduced morbidity and mortality in low-birthweight infants. Despite these and other health benefits, KC has not been implemented systematically or consistently in NICUs following current WHO guidelines. The NeoIPC project aims to optimize KC practices in NICUs and to determine the effect on severe neonatal infections and resistant bacterial colonization among high-risk infants.

methodsWithin the NeoIPC project, NeoDeco is a multi-center, parallel-group, cluster-randomized type 2 hybrid effectiveness-implementation study with 24 NICUs from five European countries representing clusters. NeoImplement, comprising the implementation elements of NeoDeco, focuses on (1) providing implementation support to sites in the intervention arm of the study and (2) evaluating the implementation of optimized KC in intervention sites. Implementation support consists of core implementation strategies that are offered to all intervention sites as well as the co-design of tailored implementation strategies for each individual site. Innovative methods supporting this co-design process are presented in this protocol. The implementation evaluation comprises a mixed-methods longitudinal study evaluating barriers and facilitators and various implementation outcomes, including a comprehensive economic evaluation. DISCUSSION: NeoImplement focuses on implementing optimized KC in participating NICUs by offering and co-developing strategies that can be sustained beyond the duration of the study. The accompanying implementation evaluation will provide insights into the effectiveness, feasibility, acceptability, sustainability, and cost-effectiveness of strategies targeting the implementation of optimized KC in European NICUs. A long-term goal of the study is to develop strategies for implementing KC that can be applied by NICUs beyond this study and to present an approach for how KC champions in NICUs themselves can develop context-sensitive implementation strategies.

trial registrationNCT05993442, December 27, 2024 https://classic. CLINICALTRIALS: gov/ct2/history/NCT05993442 .

Indexed as

Cross InfectionInfection ControlIntensive Care Units, NeonatalKangaroo-Mother Care MethodEuropeHumansImplementation ScienceInfant, NewbornMulticenter Studies as TopicRandomized Controlled Trials as TopicHybrid implementation-effectiveness studyImplementation capacity buildingInfection prevention and controlKangaroo careNeonatal intensive care

Identifiers

PMID41749274
PMCPMC13059342

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.