Evidence map›Paper›PMID 41749262›Full record

ArticleBMC medicine2026

Objective assessment of long-term impact of COVID-19 on multiple sensory functions.

Ahmad Odeh, Veronica L Formanek, Christina Smith, Nidhi Jha, Junichi Tajino, Jessica H Lewis, Lauren Gastineau, Shivani Patel, Songzhu Zhao, Lai Wei and 5 more

Abstract read
In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ahmad Odeh *Department of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Veronica L Formanek *Department of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Christina Smith *Department of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Nidhi JhaDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Junichi TajinoDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Jessica H LewisDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Lauren GastineauDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Shivani PatelDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Songzhu ZhaoDepartment of Biomedical Informatics and Center for Biostatistics, The Ohio State University, Columbus, USA.
Lai WeiDepartment of Biomedical Informatics and Center for Biostatistics, The Ohio State University, Columbus, USA.
Aaron C MoberlyDepartment of Otolaryngology, Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, USA.
Daniel M MerfeldDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA.
Christopher T SimonsDepartment of Food Science and Technology, The Ohio State University, Columbus, USA.
Megan J KobelDepartment of Speech, Language, and Hearing Sciences, University of Arizona, Tucson, USA. mkobel@arizona.edu.
Kai ZhaoDepartment of Otolaryngology, Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, USA. zhao.1949@osu.edu.

Funding

Short-term and long-term impact of COVID-19 on multiple sensory systemsR01DC020737 · NIDCD · OHIO STATE UNIVERSITY · PI KAI ZHAO · 2023 to 2026
$2.1M
NIDCD NIH HHS R01 DC020737
6 · The paper itself

Abstract

backgroundThis ongoing study investigates the impact of post-acute sequelae of SARS-CoV-2 infection (PASC) on broad sensory functions.

methodsSixty subjects aged 27-78 years were recruited who had contracted COVID-19 between 1/17/2020 and 12/21/2023 and had persistent symptoms (4.3-52.9, median = 27.48 months). Quantitative sensory assessments included (1) smell: 9-Item NIH toolbox odor identification, detection threshold to phenyl-ethyl alcohol, and retronasal candy test; (2) taste: modified NIH toolbox; (3) chemesthesis: nasal menthol lateralization thresholds and oral capsaicin identification; (4) hearing: pure-tone audiometry, otoacoustic emissions, words-in-noise recognition, and Dichotic Digits Test; (5) vestibular/balance: video head impulse testing, Subjective Visual Vertical, vestibular perceptual thresholds, and modified Romberg balance test; and (6) cognitive assessment: The Self-Administered Gero-Cognitive Exam, Digit Symbol Substitution Test, and Trail-Making Test.

resultsOverall, subjects self-reported high and overlapping dysfunctions: 67.3% smell, 63.6% taste, 56.5% balance and dizziness, 31.8% auditory, and 51.3% brain fog or cognitive dysfunctions, with varying discrepancy to the measured and confirmed deficits (smell 65.5%, taste 16%, vestibular 31.6%, hearing 53.4%, and cognition 19.1%). Significant associations were found between confirmed vestibular and auditory impairments (p = 0.04), and cognitive impairments with central components of vestibular (p = 0.03) and auditory (p = 0.01) impairments, but not with their peripheral components. Similarly, strong associations were found between identification components of smell and taste tests (p = 0.003), which may involve more central processing, but not with threshold tests (a more peripheral process). Hospitalization significantly associated with smell (p = 0.05), cognitive (p = 0.009), vestibular (p = 0. 001), and peripheral auditory (p = 0.01) dysfunctions. Age significantly associated with auditory (p = 0.02), vestibular (p = 0.01) and central olfactory (p = 0.03) dysfunctions.

conclusionsCOVID-19 impacts sensory systems broadly and differently, both peripherally and centrally, driven in part by aging, initial disease severity, and underlying post-COVID cognitive dysfunctions. Subjective symptoms may not always be corroborated by measured deficits.

Indexed as

COVID-19Sensation DisordersAdultAgedAuditory AcuityFemaleHumansMaleMiddle AgedOlfaction DisordersPost-Acute COVID-19 SyndromeSARS-CoV-2SmellAgeusiaAnosmiaHypogeusiaHyposmiaLong COVIDLong-haul COVIDNeurologic deficitsPost COVID-19 syndromePost-COVID Conditions

Identifiers

PMID41749262
PMCPMC12955268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.