ArticleItalian journal of pediatrics2026
A retrospective, single-center analysis of clinical features and mortality risk factors in pediatric pertussis patients with severe pneumonia and encephalopathy complications in Southwest China.
Article in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectivePertussis remains a serious threat to infants and young children, especially when complicated by pneumonia or encephalopathy. This study aimed to describe the clinical features, complications, treatments, and mortality risk factors in children with pediatric pertussis patients with severe pneumonia and/or encephalopathy complications over ten years in Southwest China.
methodsA retrospective study was conducted on hospitalized children with pediatric pertussis patients with severe pneumonia and/or encephalopathy complications at the Children’s Hospital of Chongqing Medical University from 2015 to 2024. Clinical data were analyzed across groups with different complications. Mortality risk factors were identified using univariate and multivariate analyses.
resultsA total of 1,088 cases were included. Patients were grouped into severe pneumonia without encephalopathy(Group A); encephalopathy without severe pneumonia (Group B); both severe pneumonia and encephalopathy (Group C). Those with both severe pneumonia and encephalopathy (Group C). had more apnea, pulmonary hypertension, extreme leukocytosis, thrombocytosis, and Acinetobacter baumannii infection. They required more intensive treatments (P < 0.05), had longer hospital stays, and the highest mortality. Seizures were more frequent in the encephalopathy group (Group B), while elevated lactate and immunoglobulin use were less common (P < 0.05). Univariate analysis identified several factors significantly associated with mortality, including female sex, pulmonary hypertension, elevated lactic acid levels, lymphocytosis, leukocytosis, Complications of severe pneumonia, combined severe pneumonia with encephalopathy. Multivariate analysis identified pulmonary hypertension, and White blood cell count(≥30 × 10⁹/L) as independent death risk factors.
conclusionPediatric pertussis patients with severe pneumonia and/or encephalopathy complications in children is often complicated by pneumonia and/or encephalopathy, making treatment more difficult. Rising antibiotic resistance and strain differences in Bordetella pertussis may reduce treatment effectiveness. The increase in severe cases after the pandemic may be due to lower population immunity. Promoting maternal pertussis vaccination in China is urgently needed as a preventive measure.
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