ArticleBMC psychiatry2026
Frontotemporal cortical thinning and insular surface area reduction in schizophrenia with predominant negative symptoms.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have revealed brain structural deficits in patients with schizophrenia displaying predominant negative symptoms, but results remain inconsistent. The present study aimed to investigate patterns of cortical structure, including cortical thickness (CTh), grey matter volume (GMV) and surface area (SA) in schizophrenia with predominant negative symptoms and their correlations with clinical features.
methodsStructural magnetic resonance imaging was performed on 68 patients with schizophrenia displaying predominant negative symptoms and 56 healthy controls (HCs). The FreeSurfer software was used to analyze the imaging data and the support vector machine (SVM) method was used for pattern classification.
resultsCompared to HCs, patients showed reduced SA in right insular, and reduced CTh in the right parstriangularis cortex, left fusiform cortex and left precentral cortex compared to HCs. No significant correlation was observed between abnormal cortical structure of the patients with clinical parameters. SVM revealed that the CTh in the fusiform cortex could distinguish patients from HCs with values above 0.6 for sensitivity, specificity and accuracy.
conclusionsThe abnormal cortical structure in frontotemporal and insula regions might reflect the inherent pathological processes of schizophrenia, which are independent of the severity of negative symptoms. The CTh in the fusiform cortex could serve as underlying imaging markers to discriminate patients with schizophrenia from HCs.
trial registrationRegistered with ChiCTR. (identifier ChiCTR2500097853, registered at February 26th, 2025)
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