Evidence map›Paper›PMID 41749058›Full record

ArticleMagnetic resonance in medicine2026

Bright Ferritin for Non-Invasive MRI Monitoring of the Fate of Transplanted hPSC-Cardiomyocytes in the Infarcted Rat Heart.

Keyu Zhuang, Faisal J Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D W Vollett, Bradley K C Freeman, M Juliana Gomez-Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu-Qing Zhou and 3 more

Abstract read
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In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Keyu ZhuangInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0003-6282-1357
Faisal J AlibhaiMcEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-8145-4682
Beiping QiangMcEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-2482-3354
Rocco RomagnuoloMcEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.
Kyle D W VollettInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-6057-0935
Bradley K C FreemanInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0006-7253-8100
M Juliana Gomez-GarciaInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Tamilla Sadikov ValdmanMcEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.
Tameshwar GaneshLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-1279-9289
Yu-Qing ZhouInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6820-9121
Hai-Ying Mary ChengDepartment of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.ORCID 0000-0002-9292-7406
Michael A LaflammeInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5908-880X
Hai-Ling Margaret ChengInstitute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0733-9512

Funding

Canada Excellence Research Chairs, Government of Canada CRC-2020-00245Canada First Research Excellence Fund MbDC2-2019-01Canada First Research Excellence Fund MbDPEFR1-2021-04Canada Foundation for Innovation 34038Dean's Spark Professorship, University of TorontoGovernment of Canada's New Frontiers in Research Fund NFRFE-2020-00509Government of Canada's New Frontiers in Research Fund NFRFT-2022-00447Natural Sciences and Engineering Research Council of Canada RGPIN-2019-06137Ted Rogers Centre for Heart ResearchVanier (CIHR) Doctoral Scholarship
6 · The paper itself

Abstract

purposeTo demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)-derived cardiomyocytes (hPSC-CMs) longitudinally and on-demand in the rat heart.

methodsFerritin-overexpressing hPSCs were differentiated into cardiomyocytes and assessed for cell viability, contractile functional proteins, and electrophysiological properties in vitro. In an immunodeficient rat model, hPSC-CMs injected into the left ventricular myocardium were tracked on cardiac MRI at 3 Tesla over 8 weeks in both healthy and infarcted hearts. Longitudinal MRI was accompanied by MnCl

resultsFerritin-overexpressing hPSC-CMs displayed normal morphological and functional phenotypes and created viable grafts in vivo. On-demand recall of bright contrast on MRI was achieved, regardless of interval post-cell transplantation, via MnCl

conclusionBright ferritin MRI allows longitudinal, non-invasive, and on-demand imaging of the distribution of viable transplanted hPSC-CMs in the healthy and infarcted rat heart.

Indexed as

Cell TrackingFerritinsMagnetic Resonance ImagingMyocardial InfarctionMyocytes, CardiacPluripotent Stem CellsAnimalsChloridesContrast MediaHumansMaleManganese CompoundsRatsChloridesContrast MediaFerritinsmanganese chlorideManganese Compoundscardiomyocytecell trackingferritinhuman pluripotent stem cellmanganesemolecular imaging

Identifiers

PMID41749058
PMCPMC13156431

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.