ArticleMikrochimica acta2026
Dual-mode colorimetric/fluorescence nitrite sensor enabled by CoFeMn hydroxide nanoflower nanozyme.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A dual-mode sensor integrating colorimetric and fluorescent functionalities was constructed to enable sensitive, on-site visual detection of nitrite in food matrices, with CoFeMn hydroxide nanoflowers (CoFeMn HNFs) serving as a novel oxidase-mimicking nanozyme. First, the successful synthesis of CoFeMn HNFs was confirmed through a series of characterization techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). Then, the synthesized CoFeMn HNFs, which exhibit remarkable oxidase-like activity, effectively catalyzed the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) to its blue oxidized form (ox-TMB) via the generation of superoxide anion radicals (O2•⁻). Its Km and Vmax values reached 0.399 mM and 2.8 × 10−7 M·s−1, respectively, demonstrating not only significantly higher catalytic activity than horseradish peroxidase (HRP) but also efficient catalysis without the requirement of H2O2. In the presence of nitrite, ox-TMB undergoes a diazotization reaction to form yellow diazo products, accompanied by a distinct fluorescence quenching effect. In the colorimetric mode, the sensor exhibited an excellent linear response to nitrite over the concentration range 0.2 to 40 µg/mL, accompanied by a limit of detection (LOD) as low as 0.063 µg/mL. For the fluorescence mode, a superior linear range of 0.3 to 40 µg/mL was achieved, with a LOD of 0.223 µg/mL nitrite. The results generated by this dual-mode sensor for real food samples were highly consistent with the reference values from the national standard method, thereby confirming its accuracy and practical utility. This work presents a versatile, reliable, and cost-effective nanozyme-based platform that addresses a critical need for sensitive, rapid, and on-site nitrite monitoring in food products, with broad implications for improving food safety surveillance and protecting public health.
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