Evidence map›Paper›PMID 41748969›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2026

A Novel Chestnut Protein Hydrolysate-Zinc Chelate: Chelation Mechanism, Antioxidant, Bioaccessibility and Cytotoxicity.

Minhui Luo, Wen Zhang, Sien Zheng, Fang Yang, Chenyang Xie

Abstract read
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In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minhui LuoSchool of Environmental Ecology and Biological Engineering, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Wen ZhangSchool of Environmental Ecology and Biological Engineering, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Sien ZhengSchool of Environmental Ecology and Biological Engineering, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Fang YangSchool of Environmental Ecology and Biological Engineering, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China. yangfang2001@126.com.
Chenyang XieSchool of Environmental Ecology and Biological Engineering, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China. abbeycyxie@163.com.

Funding

Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Grant No. LKF202401Graduate Innovative Fund of Wuhan Institute of Technology Grant No. CX2024384Open Project of Key Laboratory of Green Chemical Engineering Process of Ministry of Education Grant No. GCP2024006the National Natural Science Foundation of China No. 31701604
6 · The paper itself

Abstract

Zinc is an essential micronutrient which must be obtained through dietary intake or supplementation, while its biological accessibility in the human body is limited by phytic acid and others. To develop highly bioavailable zinc supplements, chestnut protein hydrolysate (CPH) was used to prepare a novel chestnut protein hydrolysate-zinc chelate (CPH-Zn), and the zinc chelation efficiency of CPH-Zn was 53.85 ± 5.31%. Characterization results revealed that zinc binding induced the conformational changs in CPH by coordinating with carboxy oxygen, nitrogen atoms of amide, and nitrogen atoms of amino groups. In addition, zinc chelation significantly altered the surface charge of peptide, and the chelate exhibited a porous network with increased surface roughness. Moreover, the CPH-Zn demonstrated superior antioxidant activities and low cytotoxicity at concentrations below 0.6 mg/mL. Notably, during simulated gastrointestinal digestion, zinc solubility of CPH-Zn (17.14 ± 1.91%) was significantly higher than that of ZnSO4 (6.73 ± 0.56%). These results presented the transformation of a chestnut by-product into CPH-Zn as a safe chelate that overcame bioaccessibility limitations, providing an effective zinc supplementation in human nutrition and animal feed.

Indexed as

AntioxidantsChelating AgentsFagaceaePlant ProteinsProtein HydrolysatesZincAnimalsBioactive Peptides, DietaryBiological AvailabilityDietary SupplementsDigestionHumansSolubilityAntioxidantsBioactive Peptides, DietaryChelating AgentsPlant ProteinsProtein HydrolysatesZincAntioxidantCharacterizationChestnut protein hydrolysateSimulated gastrointestinal digestionZinc supplement

Identifiers

PMID41748969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.