Evidence map›Paper›PMID 41748954›Full record

Trial reportSurgical endoscopy2026

Predictive nomogram for postsurgical gastroparesis syndrome and survival outcomes following distal gastrectomy: an in-depth analysis.

Chuanqi Chen, Jinghao Guo, Meng Wei, Yongqi Yan, Menghui Wang, Honglei Wang, Zepeng Yan, Yangjia Li, Yihang Xu, Zhibo Yan and 1 more

Abstract readClinical Trial
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In one paragraph

Trial report in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Chuanqi Chen *Department of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Jinghao Guo *Department of Gastrointestinal Surgery, The Affiliated Central Hospital of Shandong First Medical University, Jinan, 250013, China.
Meng WeiDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Yongqi YanDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Menghui WangDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Honglei WangDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Zepeng YanDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Yangjia LiDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Yihang XuDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China.
Zhibo YanDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China. Zhiboyan@sdu.edu.cn.
Wenbin YuDepartment of General Surgery, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, China. wenbin_yu2003@163.com.

Funding

the Horizontal project of Shandong University No.26010111002107the Horizontal project of Shandong University No.26010111002330
6 · The paper itself

Abstract

backgroundPostsurgical gastroparesis syndrome (PGS) is a common complication after distal gastrectomy that impairs quality of life and increases healthcare costs, yet its risk factors and long-term prognostic impact remain unclear.

objectiveTo identify PGS risk factors after radical distal gastrectomy, develop and validate a model, and assess its association with long-term survival.

methodsWe retrospectively analyzed patients undergoing radical distal gastrectomy at Qilu Hospital of Shandong University between January 2012 and December 2023. Patients were assigned to training and validation cohorts by surgery date. Logistic regression was used to identify independent risk factors and develop a PGS prediction nomogram. Propensity score overlap weighting (PSOW) was applied to reduce confounding, and the prognostic impact of PGS was assessed using weighted Kaplan-Meier analysis, log-rank tests, and Cox regression.

resultsA total of 2490 patients were included (training cohort: 1934 [77.7%]; validation cohort: 556 [22.3%]), among whom 238 developed PGS (training cohort: 187). Independent risk factors included prolonged operative time (OR = 1.01), intellectual work (OR = 2.02), well-controlled diabetes (OR = 3.10), poorly controlled diabetes (OR = 4.95), history of constipation (OR = 2.46), preoperative pyloric obstruction (OR = 3.77), perioperative psychiatric symptoms (OR = 4.60), and Billroth II (OR = 3.07) or Roux-en-Y anastomosis (OR = 6.29). Protective factors were higher preoperative plasma albumin (OR = 0.96) and laparoscopic surgery (OR = 0.47) (all p < 0.05). The nomogram showed good discrimination and calibration, with AUCs of 0.81 for the training cohort, 0.81 for internal validation, and 0.82 for temporal validation. Patients with PGS exhibited significantly worse survival outcomes, and PGS was independently associated with poorer survival in the overlap-weighted analysis (HR 1.41, 95% CI 1.12-1.79, p = 0.004).

conclusionsThe nomogram prediction model based on the risk factors for PGS occurrence has potential value in predicting the onset of PGS. PGS is significantly associated with the prognosis of patients after radical surgery for distal gastric cancer. CLINICAL

trial registrationThis study was registered at the Chinese Clinical Trial Registry (Registration No.: ChiCTR2300069234).

Indexed as

GastrectomyGastroparesisNomogramsPostoperative ComplicationsFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsNomogramPostsurgical gastroparesis syndromePrognosisRadical gastrectomy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.