Evidence map›Paper›PMID 41748901›Full record

ArticleCell death and differentiation2026

Selenoprotein thioredoxin reductase 1 promotes cancer cells ferroptosis by suppressing GPX4 expression.

Jing Luan, Jiyuan He, Dantong Wu, Yaning Duan, Guoyuan Hou, Shuang Ma, Jianhua Qin, Na Sun, Yuanzheng He, Wei Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing LuanThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.ORCID 0000-0002-6928-7631
Jiyuan HeThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Dantong WuDepartment of Laboratory Diagnostics, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, 26 Heping Road, Harbin, 150040, China.
Yaning DuanThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Guoyuan HouThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Shuang MaThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Jianhua QinThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Na SunThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Yuanzheng HeThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Wei ZhangDepartment of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA. weizhang19823@gmail.com.ORCID 0000-0002-6129-0772
Minghui GaoThe HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China. gaominghui@hit.edu.cn.ORCID 0000-0003-1725-4771

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31871388Natural Science Foundation of Heilongjiang Province YQ2020C031
6 · The paper itself

Abstract

Ferroptosis is a type of regulated necrosis driven by iron-dependent lethal accumulation of lipid peroxides. Selenoprotein thioredoxin reductase (TrxR) plays crucial roles in cellular redox homeostasis. However, its role in ferroptosis remains unclear. Here, we report TrxR1 positively regulates ferroptosis. The selenocysteine of TrxR1 is required for its regulation of ferroptosis. Mechanistically, the CRL4A

Indexed as

FerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseThioredoxin Reductase 1AnimalsCell Line, TumorHumansKelch-Like ECH-Associated Protein 1MiceMice, NudeNF-E2-Related Factor 2UbiquitinationKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseThioredoxin Reductase 1TXNRD1 protein, human

Identifiers

PMID41748901
PMCPMC13545262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.