Evidence map›Paper›PMID 41748845›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Associations of personality profiles with stress and resilience characteristics among patients undergoing cancer chemotherapy.

Alex Preston, Kennedy LaPray, Bruce A Cooper, Steven M Paul, Marilyn J Hammer, Jon D Levine, Yvette P Conley, Frances Cartwright, Christine Miaskowski, Laura B Dunn

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alex PrestonDepartment of Psychiatry, University of Arkansas for Medical Sciences, 4301 W. Markham St., #554, Little Rock, AR, 72205-7199, USA.
Kennedy LaPrayDepartment of Psychiatry, University of Arkansas for Medical Sciences, 4301 W. Markham St., #554, Little Rock, AR, 72205-7199, USA.
Bruce A CooperSchool of Nursing, University of California, San Francisco, San Francisco, CA, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, San Francisco, CA, USA.
Marilyn J HammerDana-Farber Cancer Institute, Boston, MA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Frances CartwrightDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, San Francisco, CA, USA.
Laura B DunnDepartment of Psychiatry, University of Arkansas for Medical Sciences, 4301 W. Markham St., #554, Little Rock, AR, 72205-7199, USA. Ldunn@uams.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe relationship between personality and stress and resilience has been relatively underexplored among patients undergoing chemotherapy (CTX). This study investigated these associations in adults undergoing CTX for solid tumors.

methodsIn this observational study, 1,248 patients receiving CTX for breast, gastrointestinal, gynecological, or lung cancer, completed the NEO Five-Factor Inventory (NEO-FFI) measures of life stress (Life Stressor Checklist-Revised; LSC-R; exposure and affected scores), cancer-related distress (Impact of Event Scale-Revised; IES-R), perceived stress (Perceived Stress Scale; PSS), and resilience (Connor-Davidson Resilience Scale; CD-RISC-10). Differences among three (previously described) latent personality profiles (i.e., Distressed, Normative, Resilient) in stress and resilience characteristics were examined using ANOVA, Kruskal-Wallis, or chi-square tests.

resultsThe Distressed class reported significantly higher IES-R total and subscale scores, higher PSS scores, and greater affected (but not total) LSC-R scores than both other classes (all p < .001). The Resilient class demonstrated the lowest cancer-related distress and perceived stress, and the highest CD-RISC-10 scores, compared to Normative and Distressed classes (all p < .001). Although total number of life stressors differed only between Distressed and Resilient groups, the perceived impact of specific stressors (e.g., childhood abuse, financial hardship) was greater in the Distressed class.

conclusionsDistinct personality profiles, as defined by Big Five dimensions, are strongly associated with differential levels of cancer-related distress, perceived stress, and resilience among CTX patients. Identification of individuals with "Distressed" personality profiles may facilitate early identification of patients who could benefit from early psychosocial assessment or interventions.

Indexed as

Antineoplastic AgentsNeoplasmsPersonalityResilience, PsychologicalStress, PsychologicalAdultAgedFemaleHumansMaleMiddle AgedSubjective StressAntineoplastic AgentsCancerCancer-related distressChemotherapyLatent profile analysisLife stressorsOncologyPersonalityResilience

Identifiers

PMID41748845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.