Evidence map›Paper›PMID 41748741›Full record

ReviewNature reviews. Urology2026

Urinary tract infections in children.

Preeti P John, Laura Mike, Indira U Mysorekar, Juan de Dios Ruiz-Rosado, Menna Clatworthy, Laura Schwartz, Christina Ching, Denise Kimbrough, Nader Shaikh, Luis Braga and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Preeti P JohnThe Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4942-2891
Laura MikeDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3368-4184
Indira U MysorekarDepartment of Medicine, Section of Infectious Diseases and Department of Molecular Virology and Microbiology, Huffington Center of Aging, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3917-8677
Juan de Dios Ruiz-RosadoThe Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-6429-9086
Menna ClatworthyCellular Genetics, Wellcome Sanger Institute, Hinxton, UK.
Laura SchwartzThe Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4056-3030
Christina ChingThe Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3396-4215
Denise KimbroughThe Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Nader ShaikhDivision of General Academic Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1602-343X
Luis BragaDivision of Urology, McMaster Pediatric Surgery Research Collaborative, Department of Surgery, and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Evan RajadhyakshaDivision of Pediatric Nephrology and Hypertension, Riley Hospital for Children, Indianapolis, IN, USA.
David HainsDivision of Pediatric Nephrology and Hypertension, Riley Hospital for Children, Indianapolis, IN, USA.
Joshua WatsonDivision of Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-0079-937X
Brian BecknellThe Kidney and Urinary Tract Center, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Brian.Becknell2@nationwidechildrens.org.ORCID http://orcid.org/0000-0002-2750-4415

Funding

Contrasting roles for neutrophils and macrophages during acute pyelonephritisK01DK128379 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RUIZ ROSADO, JUAN DE DIOS · 2021 to 2025
$719k
NIDDK NIH HHS K01 DK128379
6 · The paper itself

Abstract

Bacterial urinary tract infections (UTIs) are prevalent in childhood and adolescence. Paediatric UTIs present unique challenges with respect to diagnosis, prevention and management, and the potential for adverse sequelae. Uropathogenic Escherichia coli (UPEC) accounts for the majority of UTIs and is the best studied uropathogen. Novel discoveries have advanced our understanding of host-pathogen interactions, cellular and molecular mechanisms of host defence, and risk factors for UTI recurrence. Emerging evidence also highlights an association of the gut, vaginal and urinary microbiota in influencing UTI risk and recurrence. Yet, key knowledge gaps persist regarding UTI pathogenesis, host susceptibility, optimal diagnostic and management strategies and prevention of UTI recurrence and sequelae, especially in paediatric populations. The development of standardized clinical pathways offers an opportunity to improve care consistency and outcomes by integrating evidence-based practices into routine management. As technologies evolve and understanding deepens, future efforts must integrate host, microbial and clinical insights to optimize UTI prevention and treatment in paediatric populations.

Indexed as

Urinary Tract InfectionsAdolescentAnti-Bacterial AgentsChildEscherichia coli InfectionsFemaleHumansRisk FactorsUropathogenic Escherichia coliAnti-Bacterial Agents

Identifiers

PMID41748741
PMCPMC13449595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.