ArticleEye (London, England)2026
Incidence of post-traumatic endophthalmitis following repaired open globe injury: impact of prophylactic intracameral moxifloxacin.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesTo assess the effect of intracameral moxifloxacin (ICM) after repaired open globe injury (OGI) in reducing the incidence of post-traumatic endophthalmitis. SUBJECTS/
methodsAmbispective, consecutive, comparative study of patients operated of OGI repair. Patients were divided into two groups: those without intracameral antibiotic prophylaxis (No-ICM) (operated between 2002 and 2012) and those with ICM prophylaxis at the end of the procedure (ICM) (operated between 2013 and 2023). Both received standard povidone-iodine antisepsis. Endophthalmitis was defined as severe intraocular inflammation associated with hypopyon and/or vitritis.
results424 eyes (424 patients) were included, 294 in ICM group and 130 in No-ICM group. Male sex was 85.7% and 90.8% in ICM and No-ICM groups, respectively. The ICM group was significantly older than No-ICM group (median (IQR): 26 (14-41) vs. 21.5 (12-34), p = 0.025). The proportion of patients younger than 18 years was similar between ICM and No-ICM group (33.1% vs. 38.5%, p = 0.275). Post-traumatic endophthalmitis was significantly lower in ICM (2/294, 0.7%) compared to No-ICM (5/130, 3.9%) (p = 0.031) group. Sensitivity analysis age-adjusted confirmed the protective effect of ICM for endophthalmitis after OGI was independent of age (adjusted OR: 0.20; 95% CI: 0.04-0.86; p = 0.031). The relative risk of endophthalmitis with ICM compared with no-ICM was 0.18 (0.04-0.78), with relative risk reduction of 82%, absolute risk reduction of 3.2%, and a number needed to treat of 32 to prevent one case of endophthalmitis following OGI repair.
conclusionsICM at the end of surgery reduces the incidence of post-traumatic endophthalmitis after OGI repair, compared with no intracameral antibiotic prophylaxis.
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