ArticleNPJ Parkinson's disease2026
Serotonergic cortico-limbic and executive network dysfunction in Parkinson's disease impulse control disorders: a PET-fMRI study.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Impulse control disorders (ICDs) affect up to 45% of Parkinson's disease (PD) patients, yet their neural mechanisms remain unclear. Using multimodal PET and resting-state fMRI in 23 PD patients (11 PDICD + , 12 PD-ICD-) and 14 healthy controls, we identified specific brain pathways underlying ICDs. PDICD+ patients showed steeper delay discounting and altered functional connectivity, including enhanced posterior parietal coupling within executive networks and disrupted salience-executive interactions. Critically, aberrant right supplementary motor area-amygdala connectivity was linked to ICD severity and decisional impulsivity. Path analysis revealed that increased SMA 5-HT₂ₐ receptor availability was associated with enhanced SMA-amygdala coupling, which in turn was positively associated with ICD symptoms. By linking serotonergic dysfunction to disrupted motor-limbic networks and impulsive behavior, this study identifies targetable pathways for managing a common non-motor complication of PD.
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