Evidence map›Paper›PMID 41748650›Full record

ArticleNature communications2026

Molecular insights into mRNA export regulation by the human TREX-2 complex.

Xing Gong, Ran Tao, Xiaofei Ge, Huihui Zhu, Mengqi Li, Yufang Chen, Yongxiang Gao, Jing Hang, Xiaofeng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xing Gong *Center for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.ORCID http://orcid.org/0009-0005-7358-905X
Ran Tao *Center for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.ORCID http://orcid.org/0009-0008-8504-4040
Xiaofei Ge *Health and Wellness, City University of Macau, Macau, China.ORCID http://orcid.org/0009-0005-9626-7061
Huihui Zhu *Center for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Mengqi LiCenter for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Yufang ChenCenter for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Yongxiang GaoCenter for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Jing HangDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, State Key Laboratory of Female Fertility Promotion, Peking University Third Hospital, Beijing, China. hangjbysy@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-0334-6467
Xiaofeng ZhangCenter for Reproduction and Genetics, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, MOE Key Laboratory for Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, The USTC RNA Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. xiaofengzhang@ustc.edu.cn.ORCID http://orcid.org/0000-0002-9658-5917

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32471302
6 · The paper itself

Abstract

The nuclear export of mRNA represents a critical regulatory node in eukaryotic gene expression. This process is orchestrated by two conserved multi-subunit assemblies: the transcription-and-export complex (TREX) and TREX-2. While TREX facilitates mRNP packaging through multivalent RNA-protein interactions, the precise mechanism by which TREX-2 contributes to mRNA export has remained elusive. Here, we report a functional interaction between UAP56 and TREX-2 and resolve the structures of TREX-2 in both apo and UAP56-bound states. UAP56 engages TREX-2 via its N-terminal region, positioning its RecA domains on the V-shaped surface of the complex. A conserved loop from TREX-2 inserts between the RecA domains of UAP56, stabilizing an open conformation. Biochemical assays demonstrate that TREX-2 significantly stimulates the ATPase activity of UAP56, thereby promoting RNA release. These findings provide structural and mechanistic insights into TREX-2-mediated regulation of mRNA export through UAP56 remodeling.

Indexed as

DEAD-box RNA HelicasesPhosphoproteinsRNA, MessengerActive Transport, Cell NucleusExodeoxyribonucleasesHumansModels, MolecularProtein BindingRibonucleoproteinsRNA-Binding ProteinsRNA TransportDDX39B protein, humanDEAD-box RNA HelicasesExodeoxyribonucleasesPhosphoproteinsRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerTREX2 protein, human

Identifiers

PMID41748650
PMCPMC13061915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.