ArticleNature communications2026
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor.
Emily P Hardy, A Nasim Haider, Maulin M Patel, Vasyl Nesin, Hanh T M Hoang, Sandra E Gostynska, William L Berry, Augen A Pioszak, Mohiuddin Ahmad, Stephen C Parnell and 1 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Emily P HardyDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Maulin M PatelDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Vasyl NesinDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Hanh T M HoangDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Sandra E GostynskaDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Augen A PioszakDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Stephen C ParnellDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
Funding
Polycystin Function Resource Development CoreU54DK126126 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Alan S Yu · 2020 to 2026
$5.8MRAMP-altered Class B GPCR Hormone RecognitionR01GM104251 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PIOSZAK, AUGEN A · 2012 to 2024
$4.2MRegulation of Oxytocin Receptor Signaling in NeuronsR01MH125998 · NIMH · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Mohiuddin Ahmad · 2022 to 2026
$1.8MMECHANISMS DRIVING THE FORMATION OF POST-OPERATIVE PERITONEAL ADHESIONSR35GM142786 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BERRY, WILLIAM L · 2021 to 2025
$1.8MNIDDK NIH HHS U54 DK126126NIGMS NIH HHS R01 GM104251NIMH NIH HHS R01 MH125998U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) F31DK30605U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK59599U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U54DK126126U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM104251U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM142786U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH125998
6 · The paper itselfAbstract
The human genome contains approximately 800 G protein-coupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, we show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP) channel architecture, functions as a GPCR with unique biochemical properties. PKD1 acts as a WNT-activated receptor, directly coupling to heterotrimeric Gα
Indexed as
Receptors, G-Protein-CoupledTRPP Cation ChannelsWnt ProteinsAnimalsCell MembraneCyclic AMPHEK293 CellsHumansMutationCyclic AMPReceptors, G-Protein-CoupledTRPP Cation ChannelsWnt Proteins
Identifiers
PMID41748625
PMCPMC13061903
What OpenQuestion holds
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LicenceCC BY-NC-ND
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