ArticleNature communications2026
Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma.
Abstract readMulticenter Study
In one paragraph
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Circulating tumor DNA in neoadjuvant therapy for solid tumors.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Paul B RomesserDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. romessep@mskcc.org.ORCID http://orcid.org/0000-0001-8268-2903
Aron Bercz *Department of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Janet Alvarez *Department of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7853-959X
Caroline E KostrzewaDepartment of Epidemiology and Biostatistics, Biostatistics Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Angela AdamesDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4440-6032
Elisa K LiuDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yu-Jui HoCancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7540-024X
Natasha MohanDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Marsha ReyngoldDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rona YaegerDepartment of Medicine, Gastrointestinal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7233-5454
Diana A Roth O'BrienDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John J CuaronDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Melissa ZinovoyDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christine OlingerDepartment of Radiation Oncology, University of South Florida and Tampa General Hospital, Tampa, FL, USA.
Revathi RavellaDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jeanine LisantiDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0009-0008-1378-7662
Wini ZambareDepartment of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Vasily N AushevNatera, Inc., Austin, TX, USA.ORCID http://orcid.org/0000-0001-8003-358X
Shruti SharmaNatera, Inc., Austin, TX, USA.
Meenakshi MalhotraNatera, Inc., Austin, TX, USA.
Samuel Rivero-HinojosaNatera, Inc., Austin, TX, USA.ORCID http://orcid.org/0000-0002-3595-8273
Nathan SchauerNatera, Inc., Austin, TX, USA.
Adham JurdiNatera, Inc., Austin, TX, USA.ORCID http://orcid.org/0000-0002-2985-3053
Minetta C LiuNatera, Inc., Austin, TX, USA.ORCID http://orcid.org/0000-0002-8206-5232
Abraham WuDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2597-7091
Vonetta WilliamsDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Louise ConnellDepartment of Medicine, Gastrointestinal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Emmanouil PappouDepartment of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Devika RaoDepartment of Medicine, Gastrointestinal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Neil H SegalDepartment of Medicine, Gastrointestinal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3047-2303
Philip B PatyDepartment of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7045-2112
Martin R WeiserDepartment of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9577-7984
Andrea CercekDepartment of Medicine, Gastrointestinal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jorge MarcetDepartment of Surgery, University of South Florida and Tampa General Hospital, Tampa, FL, USA.
Julio Garcia-AguilarDepartment of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2451-0948
Chris H CraneDepartment of Radiation Oncology, Colorectal and Anal Cancer Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mithat GonenDepartment of Epidemiology and Biostatistics, Biostatistics Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8683-8477
J Joshua Smith *Department of Surgery, Colorectal Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2538-5456
Richard Tuli *Department of Radiation Oncology, University of South Florida and Tampa General Hospital, Tampa, FL, USA.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MSURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7MExpansion of Tumoroid Models for Precise Treatment of the Rectal Cancer PatientR37CA248289 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jesse Joshua Smith · 2020 to 2026
$4.3MLeveraging Radiation-Induced Senescence and PTPN2 Inhibition to Enhance Immune-Mediated Tumor Control in Rectal CancerR37CA304010 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Paul Bernard Romesser · 2025 to 2026
$1.5MInvestigating the contribution of cellular senescence to the efficacy of radiation therapy.K08CA255574 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ROMESSER, PAUL BERNARD · 2021 to 2025
$1.2MNCI NIH HHS K08 CA255574NCI NIH HHS P30 CA008748NCI NIH HHS R37 CA248289NCI NIH HHS R37 CA304010NCI NIH HHS T32 CA009501U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5T32 CA 9501-34
Abstract
Patients with anal squamous cell carcinoma (ASCC) who fail chemoradiation (CRT) have poor outcomes, underscoring the need for biomarkers to guide risk stratification. In a real-world two-center cohort of 84 adults with non-metastatic ASCC treated with curative-intent CRT, we prospectively evaluate a tumor-informed circulating tumor DNA (ctDNA) assay (Signatera
Indexed as
Anus NeoplasmsBiomarkers, TumorCarcinoma, Squamous CellCirculating Tumor DNANeoplasm Recurrence, LocalAdultAgedAged, 80 and overChemoradiotherapyFemaleHumansMaleMiddle AgedProgression-Free SurvivalProspective StudiesBiomarkers, TumorCirculating Tumor DNA
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LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.