SynthesisClinical and translational science2026
Review of Herpes Zoster Occurrence in Patients With Atopic Dermatitis Treated With JAK Inhibitors.
Synthesis in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Review of Herpes Zoster Occurrence in Patients With Atopic Dermatitis Treated With JAK Inhibitors.Clinical and translational science · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease that markedly impairs quality of life. Janus kinase inhibitors (upadacitinib, abrocitinib, and baricitinib) are effective therapies for moderate-to-severe AD but are associated with viral reactivation, particularly herpes zoster (HZ), due to immunosuppressive effects on interferon signaling and natural killer cell activity. The objective of this study was to systematically evaluate the risk of HZ among AD patients treated with JAK inhibitors (JAKis), identify key risk factors, and assess the clinical outcomes and management of HZ in this population. A systematic review of PubMed, Embase, and the Cochrane Library evaluated HZ risk in adolescents and adults with moderate-to-severe AD treated with JAK. Searches followed PRISMA guidelines using MeSH and EMTREE terms. The protocol was registered in PROSPERO (CRD420251070483). Eligible English-language studies included randomized trials, cohort studies, pooled safety analyses, and case series with ≥ 5 participants; reviews, case reports, and pediatric, animal, or in vitro studies were excluded. Data extraction was performed independently by two reviewers. The certainty of evidence was assessed using the GRADE approach. Eleven studies were included. The risk of HZ incidence appears higher in older patients. In some cases, the risk correlates with higher doses of JAK inhibitors, and a trend toward increased HZ events has been observed in Asian populations. HZ is a relevant but generally manageable adverse event in AD patients on JAKis. Risk stratification by age, dose, and comorbidities is advised. Ongoing real-world monitoring is crucial for optimizing outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.