Evidence map›Paper›PMID 41748313›Full record

ArticleThe British journal of ophthalmology2026

Malignant melanocytic lesions in clinically suspected pterygium.

Rozina Ida Hajdu, Paola Kammrath Betancor, Othmane Touirssa, Claudia Auw-Haedrich, Thomas Reinhard, Simone Nuessle

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Article in The British journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Rozina Ida HajduEye Center, Medical Center - University of Freiburg, Freiburg, Germany.
Paola Kammrath BetancorEye Center, Medical Center - University of Freiburg, Freiburg, Germany.
Othmane TouirssaEye Center, Medical Center - University of Freiburg, Freiburg, Germany.
Claudia Auw-HaedrichEye Clinic, University Hospital Basel, Basel, Switzerland.
Thomas ReinhardEye Center, Medical Center - University of Freiburg, Freiburg, Germany.
Simone NuessleEye Center, Medical Center - University of Freiburg, Freiburg, Germany simone.nuessle@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0003-4401-8344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo determine the prevalence and clinicopathological features of malignant melanocytic lesions in specimens clinically diagnosed as pterygia.

methodsThis retrospective study analysed all conjunctival specimens submitted with the clinical diagnosis 'pterygium' to the ophthalmic pathology laboratory of the Eye Center, University of Freiburg, Germany, between August 1999 and August 2024. Specimens that unexpectedly revealed a histopathological diagnosis of malignant melanocytic lesions were further reviewed for their clinical and pathological characteristics.

resultsAmong 2298 clinically presumed pterygia, seven specimens (0.30%) harboured a malignant melanocytic lesion: four (0.17%) were invasive conjunctival melanomas and three (0.13%) were high-grade conjunctival melanocytic intraepithelial lesions (C-MIL). Three of four melanomas were amelanotic or hypomelanotic (75%) or exhibited atypical temporal localisation (75%).

conclusionMalignant melanocytic lesions, though rare, may arise within or mimic pterygia. Their often amelanotic presentation can complicate clinical recognition. Routine histopathological evaluation of all excised pterygia is therefore essential to detect unexpected malignancies as conjunctival melanoma C-MIL.

Indexed as

Conjunctival NeoplasmsMelanomaPterygiumAdultAgedAged, 80 and overConjunctivaDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPrevalenceRetrospective StudiesConjunctivaEye (Tissue) BankingNeoplasiaOcular surfacePathology

Identifiers

PMID41748313
PMCPMC13539844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.