Evidence map›Paper›PMID 41748289›Full record

ArticleRNA (New York, N.Y.)2026

Canonical microRNA loss drives tumor development, implicating therapeutic efficacy of enoxacin in angiosarcoma.

Bozhi Liu, Ant Murphy, Annaleigh Benton, Lauren Gartenhaus, William Budka, Juliana M Bronzini, Samuel Hartzler, Madison E Yates, Alejandra Romero Alzate, Nimod D Janson and 5 more

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Bozhi Liu *Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0007-1631-3158
Ant Murphy *Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0002-2467-4491
Annaleigh Benton *Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0000-0001-6322-9994
Lauren GartenhausDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0003-9173-7242
William BudkaDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.
Juliana M BronziniDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0001-5246-3707
Samuel HartzlerDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0006-5288-281X
Madison E YatesDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.
Alejandra Romero AlzateDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0001-1087-8445
Nimod D JansonDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0009-0004-8795-4030
Shyaman JayasundaraPurdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0000-0003-0522-3353
Sagar UtturkarPurdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0000-0002-3453-1948
Nadia A LanmanPurdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0000-0002-1819-7070
Majid KazemianPurdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47906, USA.ORCID 0000-0001-7080-8820
Jason A HannaDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47906, USA hannaja@purdue.edu.ORCID 0000-0001-7253-7964

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Joint submission for administrative supplement proposal: HIPAA aligned storage and computing solutionR35GM138283 · NIGMS · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2020 to 2024
$2.0M
NCI NIH HHS P30 CA023168NIGMS NIH HHS R35 GM138283
6 · The paper itself

Abstract

Angiosarcoma (AS) is a rare and aggressive tumor arising within the endothelium, characterized by a high metastatic rate and poor prognosis. Our prior work established that endothelial loss of

Indexed as

EnoxacinHemangiosarcomaMicroRNAsAnimalsCell Line, TumorCell MovementDEAD-box RNA HelicasesGene Expression Regulation, NeoplasticHumansMiceMice, KnockoutRibonuclease IIIRNA-Binding ProteinsDEAD-box RNA HelicasesDGCR8 protein, humanEnoxacinMicroRNAsRibonuclease IIIRNA-Binding ProteinsangiosarcomaenoxacinmiRNAsarcoma

Identifiers

PMID41748289
PMCPMC13182615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.