Evidence map›Paper›PMID 41747729›Full record

ArticleCell2026

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease.

Ankur Garg, Skyler Y Blume, Helen Huynh, Alec M Barrios, Onurkan O Karabulut, Qian Zhao, Ayush D Midha, Adam W Turner, B Vittorio Resnick, Xuewen Chen and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ankur GargGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Skyler Y BlumeGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Helen HuynhGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Alec M BarriosGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Onurkan O KarabulutGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Qian ZhaoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Department of Medicine and Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Ayush D MidhaGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Medical Scientist Training Program, University of California, San Francisco, San Francisco CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Adam W TurnerGladstone Institutes, San Francisco, CA 94158, USA.
B Vittorio ResnickGladstone Institutes, San Francisco, CA 94158, USA.
Xuewen ChenGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
Ayushi AgrawalGladstone Institutes, San Francisco, CA 94158, USA.
JaeYeon KimDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Liuji ChenDepartment of Cell Systems and Anatomy, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Qitao RanDepartment of Cell Systems and Anatomy, University of Texas Health Science Center, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
Alison M RyanDepartment of Biochemistry & Molecular Biology, College of Medicine, Center for Advanced Spatial Biomolecule Research, Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Reece C LarsonDepartment of Biochemistry & Molecular Biology, College of Medicine, Center for Advanced Spatial Biomolecule Research, Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Mina NegahbanGladstone Institutes, San Francisco, CA 94158, USA.
Sophia C K NelsonGladstone Institutes, San Francisco, CA 94158, USA.
Andrew C YangGladstone Institutes, San Francisco, CA 94158, USA.
Michela TragliaGladstone Institutes, San Francisco, CA 94158, USA.
Reuben ThomasGladstone Institutes, San Francisco, CA 94158, USA.
Ramon SunDepartment of Biochemistry & Molecular Biology, College of Medicine, Center for Advanced Spatial Biomolecule Research, Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Mercedes ParedesDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
M Ryan CorcesGladstone Institutes, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Hening LinHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA; Howard Hughes Medical Institute, Department of Medicine and Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Isha H JainGladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Arc Institute, Palo Alto, CA 94304, USA. Electronic address: isha.jain@arcinstitute.org.

Funding

Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Redesigning a Neuron's Breath: A Modern Twist to Classical Oxygen BiologyDP5OD026398 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, ISHA HIMANI · 2018 to 2022
$2.2M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1M
Understanding and Treating NAXD Deficiency Using Vitamin B3-Based ApproachesR01NS142087 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI Isha Himani Jain · 2025 to 2026
$1.1M
Protracted Maturation of Cortical Inhibitory Neurons for the Complexity of Higher Cognitive AreasK99NS138587 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jaeyeon Kim · 2025 to 2026
$231k
Investigating the role of BCAA metabolism in regulating adiposity during systemic hypoxia.F30DK139713 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ayush Midha · 2024 to 2026
$138k
NCRR NIH HHS C06 RR018928NIDDK NIH HHS F30 DK139713NIGMS NIH HHS T32 GM136547NIH HHS DP5 OD026398NINDS NIH HHS K99 NS138587NINDS NIH HHS R01 NS142087
6 · The paper itself

Abstract

Vitamins are essential metabolites that must be obtained from external sources. In modern times, they have become widely available, leading to their ad hoc consumption. We developed a nutritional genomics framework to systematically identify monogenic diseases responsive to micronutrient modulation. Genome-wide CRISPR screens under varying vitamin B2 and B3 levels revealed dozens of candidate disease genes amenable to rescue by individual vitamins. In the vitamin B3 screen, NAD(P)HX dehydratase (NAXD) was the top hit; this enzyme repairs an aberrant, hydrated form of NADH (6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide [NADHX]), and its loss causes severe neurodevelopmental disease. In our Naxd knockout (KO) mouse, we observed NADHX accumulation, NAD

Indexed as

NiacinamideNutrigenomicsRiboflavinAnimalsBrainHumansMiceMice, KnockoutNADNADNiacinamideRiboflavinCRISPR screensgenomicsinborn errors of metabolismmetabolismNAD(H)NADH(X)NAXDniacinvitamin B3vitamins

Identifiers

PMID41747729
PMCPMC13008479

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.