Evidence map›Paper›PMID 41747655›Full record

ArticleEnvironment international2026

Long-term temperature exposure and depression incidence in the Nurses' Health Study II, a U.S.-based prospective cohort.

Unnati V Mehta, Grete E Wilt, Charlotte J Roscoe, Olivia I Okereke, Brent A Coull, Peter James, Francine Laden, Cindy R Hu, Nicole V DeVille, Jaime E Hart

Abstract read
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Unnati V MehtaDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: umehta94@gmail.com.
Grete E WiltDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Charlotte J RoscoeDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Environmental Systems and Human Health, OHSU-PSU School of Public Health, Portland, OR, United States.
Olivia I OkerekeDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, United States; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Brent A CoullDepartment of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, United States.
Peter JamesDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Department of Public Health Science, University of California, Davis School of Medicine, Davis, CA, United States.
Francine LadenDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Cindy R HuDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Nicole V DeVilleDepartment of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, NV, United States.
Jaime E HartDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
NCI NIH HHS U01 CA176726NHLBI NIH HHS U01 HL145386NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

backgroundWhile short-term temperature increases (e.g., daily) have been linked to higher rates of mental health hospitalizations, associations between longer-term temperature (e.g., annual) and mental health, particularly depression, are underexplored. The objective of this study was to examine the association between annual average temperature and depression incidence in a United States cohort.

methodsAfter excluding all participants in the Nurses' Health Study II who reported clinician-diagnosed depression or antidepressant use prior to 2001, we followed 39,339 participants across the study period between 2001 and 2019. We spatially linked 800 m2 annual average temperature estimates from the PRISM model to participants' biennially-updated residential addresses. We defined incident depression as self-report of clinician-diagnosed depression or antidepressant use. We used Cox proportional hazards models to estimate adjusted hazard ratios and 95% confidence intervals for the association between annual average temperature and incident depression. Models included demographic and lifestyle characteristics as covariates. We performed sensitivity analyses to assess the robustness of the observed association to changes in outcome definition.

findingsIn a fully adjusted model, the hazard ratio for the association between annual average temperature and incident depression was 1·06 (1·02, 1·08) per interquartile range (4·9) increase. While this estimate was mildly attenuated in sensitivity analyses considering alternative outcome definitions, the adverse association remained robust. INTERPRETATION AND

fundingOur results suggest that sustained exposure to higher temperatures is associated with chronic depression and other mental health outcomes. This work was supported by National Institutes of Health grants U01 CA176726, U01 HL145386, and P30 ES000002.

Indexed as

DepressionEnvironmental ExposureHot TemperatureTemperatureAdultFemaleHumansIncidenceMaleMiddle AgedNursesProspective StudiesUnited StatesChronic diseasesClimateDepressionEnvironmental epidemiologyMental healthTemperature

Identifiers

PMID41747655
PMCPMC13212979

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.