Evidence map›Paper›PMID 41747630›Full record

ReviewCurrent opinion in microbiology2026

Harnessing artificial intelligence for antimicrobial discovery and optimization.

Ashley E Clements, Maureen R Fieldhouse, Allison S Walker

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashley E ClementsDepartment of Chemistry, Center for Structural Biology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.
Maureen R FieldhouseDepartment of Chemistry, Center for Structural Biology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.
Allison S WalkerDepartment of Chemistry, Center for Structural Biology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA. Electronic address: allison.s.walker@vanderbilt.edu.

Funding

Machine learning approaches for the discovery, repurposing, and optimization of natural products with therapeutic potential - Supplement to support grad training of Adrian RussR35GM146987 · NIGMS · VANDERBILT UNIVERSITY · PI Allison Sara Walker · 2022 to 2026
$2.4M
Molecular Biophysics Training Grant at VanderbiltT32GM152286 · NIGMS · VANDERBILT UNIVERSITY · PI WALTER J. CHAZIN, Lauren Parker Jackson · 2024 to 2026
$1.6M
NIGMS NIH HHS R35 GM146987NIGMS NIH HHS T32 GM152286
6 · The paper itself

Abstract

The rise of antimicrobial-resistant pathogens has outpaced the traditional methods of drug discovery and development, emphasizing a need for new and innovative approaches to identifying novel antibiotics. Artificial intelligence (AI) poses new opportunities to overcome the challenges in traditional drug discovery by accelerating the identification, design, and optimization of bioactive small molecules and antimicrobial peptides. AI-driven genome mining allows for the identification and prioritization of biosynthetic gene clusters, while advanced AI models facilitate molecular property prediction, predicted binding interactions, and novel structure design. This review explores the advancements that AI has enabled in antimicrobial discovery and design, as well as its current limitations.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsArtificial IntelligenceDrug DiscoveryAntimicrobial PeptidesBacteriaDrug DesignHumansAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Peptides

Identifiers

PMID41747630
PMCPMC13374985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.