Evidence map›Paper›PMID 41747463›Full record

ArticlePoultry science2026

Attenuation mechanisms and vaccine potential of the serial passage-derived Pasteurella multocida strain PMZ8 in ducks.

Xiangfei Ji, Yao Meng, Haijing Yang, Xiaoyan Su, Qiao Yang, Juan Huang, Xumin Ou, Bin Tian, Yu He, Zhen Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiangfei JiInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yao MengInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Haijing YangInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Xiaoyan SuChengdu Research Base of Giant Panda Breeding, Sichuan Provincial Key Laboratory for the Protection of Rare and Endangered Wild Animals.
Qiao YangInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Juan HuangInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Xumin OuInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Bin TianInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Yu HeInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Zhen WuInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Mingshu WangInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China.
Anchun ChengInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China; Institute of Veterinary Immunology and Green Drugs, Veterinary Department in College of Animal Science, State Key Laboratory of Green Pesticide, Guizhou University, Guiyang, China.
Xinxin ZhaoInstitute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Research Center of Avian Diseases College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Chengdu, Sichuan, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, Sichuan, China. Electronic address: xxinzhao@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fowl cholera, caused by Pasteurella multocida, causes major losses in poultry worldwide, but its molecular pathogenesis remains poorly understood, limiting rational control. This study characterized an attenuated strain, PMZ8, obtained after 50 rounds of serial passaging from a highly virulent duck-derived isolate. Long-read whole-genome sequencing identified three fixed nonsynonymous mutations, in which Fis (R86S) and WaaF (G7R) contribute to virulence attenuation. PMZ8 exhibited an acapsular phenotype, a truncated LPS core, enhanced biofilm formation, defective envelope integrity, and increased intracellular ROS levels. Compared with the WT strain, PMZ8 presented at least a 10

Indexed as

Bacterial VaccinesDucksPasteurella InfectionsPasteurella multocidaPoultry DiseasesAnimalsSerial PassageVaccines, AttenuatedVirulenceBacterial VaccinesVaccines, AttenuatedCapsuleFowl choleraLive attenuated vaccineLPSPasteurella multocida

Identifiers

PMID41747463
PMCPMC12955121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.