Evidence map›Paper›PMID 41747368›Full record

ArticleInternational dental journal2026

Association of Gingival Crevicular Fluid Leptin Levels With Stages of Periodontitis: A Cross-Sectional Study.

Liting Xie, Zhiyou Guo, Jinhuai Lv, Chongwu Liu, Ling Chen, Yun Wu

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PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liting XieStomatological Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Stomatological Center, Affiliated Hospital of Putian University, Putian, China.
Zhiyou GuoStomatological Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jinhuai LvFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Chongwu LiuFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China. Electronic address: lcw1975@fjmu.edu.cn.
Ling ChenStomatological Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Stomatological Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. Electronic address: 2779704@qq.com.
Yun WuStomatological Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Stomatological Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. Electronic address: 1574316628@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the concentration of leptin in gingival crevicular fluid (GCF) across different stages of periodontitis according to the 2018 classification system and to investigate the association between GCF leptin levels and periodontitis stages. MATERIALS AND

methodsA total of 119 subjects were enrolled and allocated to 3 groups: periodontitis (P, n = 77), gingivitis (G, n = 21), and periodontal health (PH, n = 21). The P group was further classified into Stages I to IV periodontitis based on staging criteria. Clinical periodontal indexes were recorded. GCF samples were collected using absorbent paper points, and leptin concentrations in GCF were determined using enzyme-linked immunosorbent assay (ELISA). Spearman correlation, multivariable regression, and receiver operating characteristic (ROC) were evaluated.

resultsGCF leptin levels decreased progressively from the PH group to the G and P groups and declined further with increasing periodontitis stage (all P < .05). GCF leptin levels were negatively correlated with probing depth (PD) (r

conclusionsGCF leptin levels were significantly associated with periodontitis stages and decreased progressively with advancing disease severity. GCF leptin can provide complementary information for the assessment of periodontal disease severity. CLINICAL RELEVANCE: GCF leptin levels may serve as a complementary indicator of periodontal status and disease severity, supporting clinical assessment of periodontitis.

Indexed as

Gingival Crevicular FluidLeptinPeriodontitisAdultBiomarkersCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleGingivitisHumansMaleMiddle AgedPeriodontal Attachment LossPeriodontal IndexBiomarkersLeptinCytokineELISAGingival crevicular fluidLeptinPeriodontitisStaging

Identifiers

PMID41747368
PMCPMC12955619

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.