ArticleJMIR research protocols2026
Impact of Ocular Massage on Intraocular Pressure and Schlemm Canal Dimensions in Healthy Adults: Protocol for a Randomized Controlled Trial.
Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOcular massage has been reported to lower intraocular pressure (IOP) temporarily. This effect could be related to enhanced aqueous humor outflow; however, the mechanism is unclear.
objectiveThis study aims to examine the impact of digital and EyePeace ocular massage on IOP fluctuations and investigate whether the observed reduction in IOP is attributable to morphological changes in the Schlemm canal (SC).
methodsParticipants were randomly assigned in a 1:1:1 ratio to 1 of 3 groups: digital ocular massage, EyePeace ocular massage, or no ocular massage. The primary outcome measure will be IOP. The secondary outcome measures will include anterior segment optical coherence tomography assessment of the SC and trabecular meshwork. In addition, adverse events in the quality of vision will be monitored and documented using a mobile app-based questionnaire. All assessments will be performed at baseline and 10 minutes after the assigned interventions.
resultsData collection was completed in the summer of 2025. The study results are expected to be published by the end of 2025.
conclusionsThis study will investigate the impact of ocular massage on IOP and SC dimensions by using a randomized controlled design. As preliminary evidence suggests that ocular massage may transiently reduce IOP by enhancing aqueous humor outflow, this study will aim to clarify the underlying mechanism. By comparing digital ocular massage, EyePeace ocular massage, and no ocular massage, the study will assess changes in IOP and SC morphology. The findings are expected to provide insights into the role of mechanical manipulation in modulating aqueous humor outflow, potentially informing nonpharmacological strategies for possible glaucoma management.
trial registrationChinese Clinical Trial Registry ChiCTR2400093512; https://www.chictr.org.cn/showproj.html?proj=250459. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/78864.
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