Evidence map›Paper›PMID 41747105›Full record

ArticleThe Journal of urology2026

Patients With Urinary Urgency Have Central Sensitization Symptoms-A LURN II Phenotyping Study.

H Henry Lai, Alan J Fossa, Brian Bieber, Cindy L Amundsen, J Eric Jelovsek, Anne P Cameron, Catherine S Bradley, Karl Kreder, Claire C Yang, Alexander Glaser and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

H Henry LaiDepartment of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Alan J FossaArbor Research Collaborative for Health, Ann Arbor, Michigan.
Brian BieberArbor Research Collaborative for Health, Ann Arbor, Michigan.
Cindy L AmundsenDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Duke University, North Carolina.
J Eric JelovsekDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Duke University, North Carolina.
Anne P CameronDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Catherine S BradleyDepartment of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Karl KrederDepartment of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Claire C YangDepartment of Urology, University of Washington, Seattle, Washington.
Alexander GlaserDivision of Urology, Department of Surgery, Endeavor Health, Elmhurst, Illinois.
Victor P AndreevArbor Research Collaborative for Health, Ann Arbor, Michigan.
Kimberly KentonSection of Urogynecology & Reconstructive Pelvic Surgery, Department of Obstetrics & Gynecology, University of Chicago, Chicago, Illinois.
J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Ziya KirkaliNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Steven E HarteDepartments of Anesthesiology and Internal Medicine, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, Michigan.

Funding

Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating CenterU24DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI GRAFF, JOHN JOSEPH · 2019 to 2025
$6.9M
Phenotype of urinary symptoms and relationships with genotype, sleep and obesityU01DK097779 · NIDDK · UNIVERSITY OF CHICAGO · PI GRIFFITH, JAMES WILLIAM, KENTON, KIMBERLY SUE · 2012 to 2025
$5.7M
Advancing the Measurement and Classification of Lower Urinary Tract DysfunctionU01DK097780 · NIDDK · DUKE UNIVERSITY · PI AMUNDSEN, CINDY, JELOVSEK, JOHN ERIC · 2012 to 2025
$5.3M
University of Iowa LURN Research SiteU01DK097772 · NIDDK · UNIVERSITY OF IOWA · PI BRADLEY, CATHERINE S, KREDER, KARL J · 2012 to 2025
$5.0M
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)U01DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2013 to 2018
$4.6M
University of Washington LURN Research SiteU01DK100011 · NIDDK · UNIVERSITY OF WASHINGTON · PI YANG, CLAIRE C · 2013 to 2025
$4.5M
University of Michigan LURN Research SiteU01DK099932 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN · 2013 to 2023
$4.4M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase StudyU01DK100017 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2025
$3.9M
NIDDK NIH HHS U01 DK097772NIDDK NIH HHS U01 DK097779NIDDK NIH HHS U01 DK097780NIDDK NIH HHS U01 DK099879NIDDK NIH HHS U01 DK099932NIDDK NIH HHS U01 DK100011NIDDK NIH HHS U01 DK100017NIDDK NIH HHS U24 DK099879
6 · The paper itself

Abstract

purposeWe examined central sensitization in patients with urinary urgency, with or without urgency urinary incontinence. MATERIALS AND

methodsAdult male and female patients who presented with urinary urgency, with or without urgency incontinence, and seeking treatment for their overactive bladder (OAB) were enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) II Study. A control group without urgency or incontinence was also enrolled. Symptoms associated with central sensitization were assessed using the validated self-reported questionnaire Central Sensitization Inventory (CSI). CSI ≥ 40 is associated with a higher likelihood of having central sensitization.

resultsSix hundred seventeen cases with urinary urgency and 125 controls without urinary symptoms were included. Cases had higher CSI part A scores compared with controls (median 28.0 vs 15.0). The percentage of participants likely to have central sensitization (CSI ≥40) was significantly higher in cases vs controls (21% vs 3.2%,

conclusionsPatients with OAB with urinary urgency had more central sensitization symptoms compared with controls. Our data suggested that central sensitization may play a role in at least a subset of patients with urinary urgency, with or without urgency urinary incontinence.

Indexed as

Central Nervous System SensitizationUrinary Bladder, OveractiveUrinary Incontinence, UrgeAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPhenotypeSurveys and Questionnairescentral sensitizationoveractive bladderphenotyping

Identifiers

PMID41747105
PMCPMC13191570

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.