SynthesisClinical and experimental dental research2026
Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis.
Synthesis in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664046 (A Three-arm Randomized Controlled Trial Evaluating the Effectiveness of Self- Assembling Peptide P11-4 in the Remineralization of Enamel Carious White Spot Lesions), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Three-arm Randomized Controlled Trial Evaluating the Effectiveness of Self- Assembling Peptide P11-4 in the Remineralization of Enamel Carious White Spot Lesions
Who cites it
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObjective: To evaluate the effect of self-assembling peptide (SAP) on white spot lesions (WSLs) in orthodontic patients with fixed appliances.
methodsEligibility Criteria: Randomized and non-randomized clinical studies, as well as in vitro studies, comparing SAP with fluoride or no treatment for WSLs in orthodontic patients were included. Outcomes assessed were WSL score, lesion size, or fluorescence loss. Case reports, case series, animal studies, and narrative reviews were excluded. INFORMATION SOURCES: Comprehensive literature search of six databases was conducted up to May 16, 2025. Risk of Bias: Risk of bias was assessed using tools appropriate to each study design: RoB-2 for randomized controlled trials, ROBINS-I for non-randomized studies, and QUIN for in vitro studies. SYNTHESIS OF
resultsRandom effects meta- analyses using standardized mean differences (SMDs) and their 95% confidence intervals (CIs) were performed, followed by subgroup, sensitivity analyses, and assessment of the quality of evidence was done using GRADE approach.
resultsIncluded Studies: Eight studies (five randomized, two non-randomized prospective, one in vitro) involving 395 participants were included. SYNTHESIS OF
resultsMeta-analysis of eight studies showed a significant reduction in severity of WSLs with SAP compared to fluoride or control (SMD = -1.68; 95% CI: -2.71 to -0.67; p = 0.005), but with high heterogeneity (I DISCUSSION: Limitations of Evidence: The study is limited by the inclusion of less number of studies, one in-vitro study, and some non-randomized trials. INTERPRETATION/
conclusionIt can be concluded that very low-level evidence is available that SAP can reduce the severity of WSLs associated with fixed orthodontic treatment more effectively than topical fluoride or no treatment. REGISTRATION: PROPSERO Registration Number: (CRD420251112657).
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