ArticleWomen's health (London, England)
Pretreatment computed tomography L1 attenuation values: Easy reaching predicting factor for radiation-related bone insufficiency fractures in females treated for advanced cervical cancer (prospective study).
Article in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRadiotherapy (RT) brings a broad spectrum of side effects that could affect patient well-being. Pelvic insufficiency fractures (PIF) are one of them.
objectivesThe aim of our study was to identify easily detectable risk factors for radiation-related PIF.
designProspective, single-center study.
methodsWe included 104 patients aged 52.9 ± 13.8 years following radical RT for advanced cervical cancer. Patients underwent a pretreatment computed tomography (CT) imaging and a minimally 1-year follow-up by CT or magnetic resonance imaging. We evaluated the association between pretreatment CT attenuation values of L1, their deviation from normative values, age, body mass index, total received radiation dose, smoking habits, and radiation-related bone side effects.
resultsIn 28 (26.9%) patients PIF were found and first detected at a mean of 16 ± 7 months after RT. Patients with PIF were significantly older; 62.5 ± 10.2 versus 49.4 ± 12.6 years,
conclusionIncreasing age and lower pretreatment CT L1 attenuation values are strong predictors for radiation-related PIF, reflecting osteoporosis status.
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