Evidence map›Paper›PMID 41746558›Full record

ReviewEJNMMI radiopharmacy and chemistry2026

Drug interactions involving therapeutic radiopharmaceuticals: a systematic review.

Robin Gacon, Romane Chapuis, Luca Fabris-Davet, Nina Ranjit, Sylvain Goutelle, Laurent Bourguignon, Anthime Flaus, Claire Bolot, Elise Levigoureux, Matthieu Gallet and 1 more

Abstract readReview
In one paragraph

Review in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robin GaconPharmacy Department Radiopharmacy, Hospices Civils de Lyon Louis Pradel Hospital, 69677, Bron, France.
Romane ChapuisPharmacy Department Radiopharmacy, Hospices Civils de Lyon Louis Pradel Hospital, 69677, Bron, France.
Luca Fabris-DavetPharmacy Department Radiopharmacy, Hospices Civils de Lyon Louis Pradel Hospital, 69677, Bron, France.
Nina RanjitPharmacy Department, Radiopharmacy, Georges-François Leclerc Cancer Center, Dijon, France.
Sylvain GoutellePharmacy Department, Hospices Civils de Lyon Croix-Rousse Hospital, Lyon, France.
Laurent BourguignonPharmacy Department, Hospices Civils de Lyon Croix-Rousse Hospital, Lyon, France.
Anthime FlausNuclear Medicine Department, Hospices Civils de Lyon Louis Pradel Hospital, Bron, France.
Claire BolotPharmacy Department Radiopharmacy, Hospices Civils de Lyon Louis Pradel Hospital, 69677, Bron, France.
Elise LevigoureuxPharmacy Department Radiopharmacy, Hospices Civils de Lyon Louis Pradel Hospital, 69677, Bron, France.
Matthieu GalletPharmacy Department, Radiopharmacy, Georges-François Leclerc Cancer Center, Dijon, France.
Sarah ChaibPharmacy Department Radiopharmacy, Hospices Civils de Lyon Louis Pradel Hospital, 69677, Bron, France. sarah.chaib@chu-lyon.fr.ORCID http://orcid.org/0000-0001-5874-6858

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug interactions with diagnostic radiopharmaceuticals are well recognized, as they can modify biodistribution and lead to false or misleading diagnostic results. However, little is known about such interactions in the field of therapeutic radiopharmaceuticals, despite their rapid expansion-particularly with targeted radionuclide therapies such as Radioligand Therapy (RLT). This review aims, for the first time, to systematically compile and analyze available data on drug interactions involving therapeutic radiopharmaceuticals, in order to support safer and more effective patient care. MAIN BODY: Eighty-three articles investigating drug interactions with [

conclusionDrug interactions with therapeutic radiopharmaceuticals remain underreported, yet they may have significant clinical consequences. Clinical radiopharmacy plays a key role in detecting and preventing these interactions. Radiopharmacists, through their expertise, can identify potential interactions, influence therapeutic decisions, and positively impact patient management. Their involvement throughout the care pathway is essential to ensure the safe and effective use of these innovative therapies. Nuclear medicine physicians should also be aware that such interactions can alter biodistribution, compromise therapeutic efficacy, and increase the risk of adverse effects.

Indexed as

Clinical radiopharmacyDrug interactionNuclear medicineRadioligand therapy (RLT)Radiopharmaceutical interactionsTargeted radionuclide therapy (TRT)

Identifiers

PMID41746558
PMCPMC13038832

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.