Evidence map›Paper›PMID 41746462›Full record

ArticleBrain imaging and behavior2026

Gut microbiota-cognitive function interactions in patients with comorbid insomnia and sleep apnea (COMISA): a study on brain dynamic specificity.

Huiyu Chen, Hui Li, Jiawei Guo, Liping Pan, Shishun Fu, Guihua Jiang, Meng Li

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Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Huiyu Chen *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0009-4188-3552
Hui Li *People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Jiawei GuoXinjiang Medical University, Urumqi, China.
Liping PanThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Shishun FuDepartment of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Guihua JiangThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. jianggh@gd2h.org.cn.ORCID http://orcid.org/0000-0002-4735-9577
Meng LiThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. limengsecret@126.com.

Funding

National Natural Science Foundation of China U1903120Science and Technology Projects in Guangzhou 2024A03J0856
6 · The paper itself

Abstract

Cognitive impairments in comorbid insomnia and sleep apnea (COMISA) show an additive effect, but the neurophysiological mechanisms remain unclear. This study explored the links between brain dynamic functional activity, gut microbiota (GM), and cognitive changes in COMISA patients. Twenty-five COMISA patients and 22 healthy controls (HCs) underwent fMRI scanning and cognitive function assessments. Dynamic regional homogeneity (dReHo) differences between groups were compared, followed by dynamic functional connectivity (dFC) analysis using regions with abnormal dReHo as seed points. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Correlations between dReHo, dFC, cognitive function, and GM were explored. The dReHo value of the right lingual gyrus was reduced in the COMISA group (P<0.05), and the dFC value between the right lingual gyrus and the left lingual gyrus and posterior cingulate gyrus was decreased in COMISA (P<0.05). Compared to HCs, GM status was altered in COMISA patients Correlation analysis showed that dReHo in the right lingual gyrus was positively correlated with MoCA scale scores. The relative abundance of Bacteroides was correlated with the indicators of abnormal brain dynamic function. Specific alterations in brain function and GM composition were identified in COMISA patients. The lingual gyrus and Bacteroides may serve as potential targets for early diagnosis and treatment.

Indexed as

BrainCognitionGastrointestinal MicrobiomeSleep Apnea SyndromesSleep Initiation and Maintenance DisordersAdultCognitive DysfunctionComorbidityFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedCognitive functionComorbid insomnia and sleep apneaDynamic functional connectivityDynamic regional homogeneityGut microbiota

Identifiers

PMID41746462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.