Evidence map›Paper›PMID 41746447›Full record

ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2026

The DNA mismatch repair protein Msh4 is essential for meiosis of male but not for female in zebrafish.

Yankun Guo, Yunbang Zhang, Yihui Mei, Yuwei Huang, Yuxuan Zheng, Nan Zhang, Yuxin Jiang, Hanjun Jiang, Zijie Zhang, Angxiao Li and 4 more

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Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yankun GuoMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Yunbang ZhangMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Yihui MeiMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Yuwei HuangMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Yuxuan ZhengMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Nan ZhangMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Yuxin JiangMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Hanjun JiangMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Zijie ZhangMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Angxiao LiMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Jinchang FanMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Katsutoshi AraiMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Jian GaoMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China.
Xiaojuan CaoMinistry of Education, College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industryin theYangtze River Economic BeltHuazhong Agricultural University, Wuhan, 430070, China. caoxiaojuan@mail.hzau.edu.cn.

Funding

Fundamental Research Funds for the Central Universities 2662025SCPY006Key R&D Plan Projects in Hubei Province of China 2023BBB054National Natural Science Foundation of China 32172962
6 · The paper itself

Abstract

Meiotic recombination plays a crucial role in the correct separation of homologous chromosomes. The DNA mismatch repair protein Msh4 is a meiosis specific protein and msh4 defects were reported to associate with azoospermia and ovarian dysfunction in mammal. However, its role has not been elucidated in an important model animal, zebrafish. Here, we examined the role of Msh4 in meiosis and gametogenesis by knocking out msh4 using CRISPR/Cas9 technology. The resultant msh4

Indexed as

CrossoverGametogenesisGenome editionSex differentiationSynapsis

Identifiers

PMID41746447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.