Evidence map›Paper›PMID 41746435›Full record

ArticleMikrochimica acta2026

A surface-enhanced Raman scattering sensor based on tetrahedral DNA-Ag@4-ATP nanostructures for ultrasensitive detection of ochratoxin A.

Liming Guo, Bo Wang, Jie Zhang, Xiangyu Ma, XiuFang Zhu, Liangdong Feng, Ying Bao, Jiadong Zhang, Yi Chen

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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liming GuoNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China.
Bo WangNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China.
Jie ZhangNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China.
Xiangyu MaNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China.
XiuFang ZhuNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China.
Liangdong FengNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China.
Ying BaoKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. bying@ciac.ac.cn.
Jiadong ZhangNational & Local Joint Engineering Research Center for Deep Utilization Technology of Mineral Salt Resource, and Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an, 223003, China. jiadongzhang@hyit.edu.cn.
Yi ChenKey Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.

Funding

Jiangsu Education Department 24KJB150005Open Fund Program of National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization SF202004the National Natural Science Foundations of China 22134007the National Natural Science Foundations of China 52503211
6 · The paper itself

Abstract

An innovative "turn-on" surface-enhanced Raman scattering (SERS) biosensor for ultrasensitive ochratoxin A (OTA) monitoring by a tetrahedral DNA nanostructure (TDN) is introduced, which provides high mechanical strength and stability. The TDN framework was engineered with an OTA-specific aptamer conjugated at one edge, while two adjacent vertices were functionalized with Ag@4-aminothiophenol (4-ATP) nanoparticles via thiolated linker strands. Upon target recognition, aptamer-OTA binding triggers a programmable conformational switching of the TDN. This switching spatially regulates the electromagnetic field coupling between adjacent Ag@4-ATP hotspots, thereby amplifying the SERS signal in a target-dependent manner. Compared to conventional SERS platforms, this strategy exhibits higher sensitivity, with a linear response over six orders of magnitude (0.39–10000 pg/mL, R2 = 0.998) and an ultralow limit of detection (LOD) of 0.117 pg/mL. Field validation using spiked peanut and soybean samples showed excellent correlation with high-performance liquid chromatography (HPLC) reference measurements, while reducing the analysis time from > 1 h to < 5 min per sample. By modifying the tetrahedral DNA sequences, this approach holds promise for the detection of multiple mycotoxins in food enhancing food safety and protecting public health.

Indexed as

Biosensing TechniquesOchratoxinsSpectrum Analysis, RamanAniline CompoundsAptamers, NucleotideArachisDNADNA NanostructuresFood ContaminationGlycine maxLimit of DetectionMetal NanoparticlesSilverSulfhydryl Compounds4-aminothiophenolAniline CompoundsAptamers, NucleotideDNAochratoxin AOchratoxinsSilverSulfhydryl CompoundsAptamerOchratoxin ASERS sensorSurface-enhanced Raman spectroscopyTetrahedral DNA nanostructures

Identifiers

PMID41746435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.