Evidence map›Paper›PMID 41746388›Full record

ArticleCell and tissue research2026

Three-dimensional structure and epithelial changes of the piriform sinus fistula in cotton rats.

Teppei Nakamura, Marina Hosotani, Osamu Ichii, Takao Irie, Akio Shinohara, Hirokazu Kouguchi, Yasuhiro Kon

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Article in Cell and tissue research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teppei NakamuraLaboratory of Laboratory Animal Science and Medicine, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-Ku, Sapporo, Hokkaido, 060-0818, Japan. nakamurate@vetmed.hokudai.ac.jp.
Marina HosotaniLaboratory of Veterinary Anatomy, Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido, 069-8501, Japan.
Osamu IchiiLaboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-Ku, Sapporo, Hokkaido, 060-0818, Japan.
Takao IrieLaboratory of Veterinary Parasitology, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Kiyotake, Miyazaki, 889-2192, Japan.
Akio ShinoharaDivision of Bio-Resources, Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan.
Hirokazu KouguchiMedical Zoology Group, Department of Infectious Diseases, Hokkaido Institute of Public Health, Kita 19, Nishi 12, Kita-Ku, Sapporo, Hokkaido, 060-0819, Japan.
Yasuhiro KonLaboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-Ku, Sapporo, Hokkaido, 060-0818, Japan.

Funding

Japan Society for the Promotion of Science JP18K0703708
6 · The paper itself

Abstract

Piriform sinus fistula (PSF) is a rare congenital anomaly derived from the third or fourth pharyngeal pouch. However, its developmental mechanisms remain poorly understood owing to the absence of suitable animal models. Cotton rats (Sigmodon hispidus) spontaneously develop PSF, providing a unique opportunity to investigate its anatomical origin and postnatal remodeling. In this study, we performed a three-dimensional reconstruction of serial histological sections from two inbred strains, HIS/Mz with third-pouch-derived PSF and HIS/Hiph with fourth-pouch-derived PSF. The third-pouch PSF opened dorsally at the base of the piriform sinus and terminated outside the thyroid gland, whereas the fourth-pouch PSF opened ventrally at the apex and extended into the thyroid parenchyma. Focusing on the fourth-pouch PSF in the HIS/Hiph, we further identified progressive epithelial stratification and age-dependent inflammation leading to suppurative thyroiditis. This remodeling was accompanied by marked alterations in epithelial marker expression, including a shift from Nkx2-1

Indexed as

FistulaPyriform SinusAnimalsEpitheliumMaleSigmodontinaeCotton ratEpithelial remodelingInflammationPharyngeal pouchPiriform sinus fistula

Identifiers

PMID41746388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.