ReviewPediatric surgery international2026
Operative and non-operative management of acute appendicitis in children: a narrative review.
Review in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appendicitis represents a prevalent medical condition among pediatric and adolescent populations, often necessitating emergency surgical procedures. For nearly two hundred years, the management of appendicitis has been conceptualized as a surgical challenge. In contemporary practice, minimally invasive techniques enable appendix removal with reduced anesthetic and operative risks, as well as shorter hospitalization. Nevertheless, both anesthesia and surgical interventions carry potential adverse effects, such as surgical site infections, hemorrhage, herniation, and visceral injury. Furthermore, postoperative convalescence may lead to absence from educational or occupational activities, accompanied by considerable medical expenditures. Recent high-quality evidence in adults and children supports a shift away from routine surgical intervention toward nonoperative strategies for managing this condition. Studies involving adult patients have confirmed that non-surgical treatment of acute appendicitis is both safe and effective. Similarly, in pediatric cases characterized by acute appendicitis, initial conservative management has been associated with a lower incidence of complications, reduced recovery time, and decreased medical expenses, while circumventing surgical risks. There have been multiple prospective clinical trials including a recent multicenter international trial comparing surgery and nonoperative management. It has been established what the safety and effectiveness of non-operative management is and how it compares to surgery. Both are safe and effective options with different risks and benefits period; future studies should focus on pathway specific improvements for non-operative management or for surgery. This review evaluates the clinical outcomes and safety of three therapeutic strategies: traditional appendectomy, endoscopic retrograde appendicitis therapy (ERAT), and conservative pharmacological management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.