ArticleNeuroradiology2026
A rare case of crescent-shaped peridentate hyperintensity preceding cerebellar atrophy in GAD65 antibody-associated ataxia.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamic acid decarboxylase 65 (GAD65) antibody-associated cerebellar ataxia (GAD65-CA) is a rare autoimmune neurological disorder wherein antibodies against the GAD65 enzyme impair GABAergic neurotransmission, ultimately causing Purkinje cell dysfunction. In this report, a 33-year-old woman exhibited right-dominant limb ataxia and dysarthria with high-titer anti-GAD65 antibodies (> 2,000 U/mL) in serum and cerebrospinal fluid. Three months after symptom onset, magnetic resonance imaging (MRI) revealed a crescent-shaped hyperintensity in the white matter surrounding the right dentate nucleus, along with hilum hyperintensity on T2-weighted imaging and fluid-attenuated inversion recovery sequences, without cerebellar atrophy. However, during follow-up, progressive right cerebellar atrophy developed, and iron accumulated within the dentate nucleus. These early MRI signal changes around the dentate nucleus suggested secondary axonal degeneration resulting from Purkinje cell injury. Therefore, this case highlights a distinctive imaging pattern, providing new insights into autoantibody-induced cerebellar synaptic impairment.
Indexed as
Identifiers
41746313What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.