ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2026
Protocol for a Randomized Clinical Trial to Evaluate Not Routinely Measuring Gastric Residual Volume to Guide Enteral Feeding Versus Routine Measurement in Mechanically Ventilated Critically Ill Children (GASTRIC-PICU).
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveProviding adequate nutrition is a key aspect of pediatric intensive care, with enteral administration preferred. The regular measurement of gastric residual volume (GRV) to guide feeding is common, but it results in frequent feed interruptions due to a perceived high GRV. The GASTRIC-PICU (GRV to guide enteral feeding vs. routine measurement in mechanically ventilated critically ill children) randomized controlled trial aims to evaluate the clinical and cost-effectiveness of not routinely measuring GRV to guide enteral feeding compared with the usual practice of routine measurement.
designMulticenter, randomized, non-inferiority, open-label clinical trial with embedded health economic evaluation.
settingTwenty-three PICUs across United Kingdom, Scotland, Northern Ireland, and Switzerland. PATIENTS: Infants and children 37 weeks old or older corrected gestational age to 16 years admitted to participating PICUs, on mechanical ventilation and being enterally fed. INTERVENTION AND COMPARISON: Standard feeding protocols without routinely measuring GRV to guide feeding will be compared against standard feeding protocols with routine (at least 6-hourly) GRV measurement to guide feeding. MEASUREMENTS AND MAIN
resultsRandomization 1:1 between no routine GRV measurement and routine GRV measurement stratified by site, age at admission, and main reason for admission. "Research Without Prior Consent" will be used. The primary clinical outcome is a composite outcome of survival and days free from mechanical ventilation at 30 days (non-inferiority). The superiority co-primary outcome is the percentage of the child's estimated energy requirements achieved by 72 hours after randomization. The primary outcome of cost-effectiveness analysis is incremental net monetary benefits at 6 months. Baseline demographics and clinical status, daily nutritional data for the first 7 days, and discharge outcome, as well as longer-term survival and economic data will be collected.
conclusionsTrial findings will be disseminated in peer reviewed journals, via international conferences and in lay language via social media.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.