ArticleExperimental physiology2026
Coupling between global brain blood oxygen level-dependent activity and cerebrospinal fluid dynamics in young endurance athletes.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Coupling between global brain blood oxygen level-dependent activity and cerebrospinal fluid dynamics in young endurance athletes.Experimental physiology · 2026Article
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Authors and funding
10 authors.
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Abstract
Cerebrospinal fluid (CSF) contributes to brain waste clearance through its coupling with cerebral haemodynamics. Aerobic exercise promotes brain health, but its influence on brain waste clearance remains unclear. This study examined the coupling between CSF and cerebral haemodynamics in endurance athletes. Fifteen young male endurance athletes were compared with 16 age-matched sedentary male controls. Resting-state functional magnetic resonance imaging was used to obtain brain global blood oxygen level-dependent (gBOLD) and CSF inflow signals. The gBOLD-CSF coupling was estimated using cross-correlation function and transfer function analyses in time and frequency domains, respectively. The magnitude of gBOLD and CSF oscillations was also quantified by power spectral density. The cross-correlation-derived gBOLD-CSF coupling was similar between athletes and sedentary controls (-0.30 ± 0.26 vs. -0.33 ± 0.22, P = 0.753). Power spectral density of the CSF inflow signal was significantly greater in athletes (2.83 [2.19, 3.47] z
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