Evidence map›Paper›PMID 41746104›Full record

ArticleVaccines2026

Immunization Against a Conserved Short 13-Amino Acid Receptor-Binding Epitope of FSHβ Reduces Spermatogenesis and Sperm Motility in Male Mice.

Xuanti Liu, Like Ran, Jingyi He, Shuhan Lei, Jiayi Zhang, Zongrui Yang, Xingfa Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuanti LiuSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.
Like RanSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.
Jingyi HeSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.
Shuhan LeiSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.
Jiayi ZhangSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.
Zongrui YangSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.
Xingfa HanSchool of Life Sciences, Sichuan Agricultural University, Ya'an 625014, China.ORCID 0000-0002-8796-2047

Funding

Science & Technology Department of Sichuan Province 2025YFHZ0181
6 · The paper itself

Abstract

backgroundFollicle-stimulating hormone (FSH)-based vaccines show the potential to disrupt spermatogenesis without disturbing sexual function and libido in males. Herein, we developed a novel FSH vaccine based on the tandem of a conserved 13-amino acid receptor-binding epitope of FSHβ (FSHβ13AA-T) and tested its effect on reproductive physiology and function using the male mouse as a model.

methodsSerum reproductive hormone levels, testicular histology, daily sperm production, sperm motility, libido and fertility of male mice following FSH vaccination were determined.

resultsCompared to placebo-immunized controls, FSH vaccination triggered (

conclusionsThese results demonstrate that immunization of male mice against FSHβ13AA could substantially inhibit spermatogenesis and reduce sperm motility. Thus, FSHβ13AA-based vaccines hold potential for development as male contraceptives that do not compromise libido in species including men in which FSH is essential for spermatogenesis.

Indexed as

follicle-stimulating hormonemicespermatogenesissperm motility

Identifiers

PMID41746104
PMCPMC12944964

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.