Evidence map›Paper›PMID 41746066›Full record

ArticleVaccines2026

Correlation Analysis Between HLA Polymorphisms and Immune Response to Hepatitis B Vaccine in Children with Acute Lymphoblastic Leukemia.

Rui Zhang, Tian Yang, Yijin Gao, Hua Zhang, Yi Fei, Laibao Yang, Pengfei Deng

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Article in Vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Rui ZhangDepartment of Immunology, Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Zhangyang Road 3039, Shanghai 200136, China.
Tian YangDepartment of Immunology, Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Zhangyang Road 3039, Shanghai 200136, China.
Yijin GaoDepartment of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0002-7592-4115
Hua ZhangDepartment of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Yi FeiDepartment of Immunology, Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Zhangyang Road 3039, Shanghai 200136, China.
Laibao YangDepartment of Immunology, Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Zhangyang Road 3039, Shanghai 200136, China.
Pengfei DengDepartment of Immunology, Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Zhangyang Road 3039, Shanghai 200136, China.

Funding

Key Discipline Program of Pudong New Area Health System PWZxk2022-25Pudong New Area Health Commission General Project PW2024A-28Pudong New Area Science and Technology Development Fund Program PKJ2023-Y34Shanghai Three-Year Action Plan for Strengthening Public Health System (2023-2025) Discipline Leader Project GWVI-11.2-XD09
6 · The paper itself

Abstract

backgroundThe human leukocyte antigen (HLA) is crucial for antigen presentation and vaccine efficacy. This study examined the association between HLA polymorphisms and the immune response to hepatitis B vaccination in children with acute lymphoblastic leukemia (ALL).

methods101 pediatric ALL patients at Shanghai Children's Medical Center affiliated with Shanghai Jiaotong University School of Medicine who tested negative for hepatitis B surface antibody (anti-HBs) and were not infected with hepatitis B received three doses of the hepatitis B vaccine. Anti-HBs titers were measured before and after vaccination. Participants were divided into high- and low-response groups based on post-vaccination anti-HBs titers. Sequence-specific primer polymerase chain reaction (PCR-SSP) was used to genotype HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles.

resultsPre-vaccination anti-HBs titers were 3.38 ± 2.97 mIU/mL, and the post-vaccination seroconversion rate was 100% with mean titers of 429.61 ± 303.13 mIU/mL (

conclusionsHLA-B*3501 may be associated with lower antibody response levels in children with ALL who completed the full hepatitis B vaccination series. All these children demonstrated protection against the hepatitis B virus (HBV). We will subsequently validate the association between HLA-B*3501 and the level of hepatitis B vaccine immune response in children with ALL through expanding the sample size or conducting a multicenter study.

Indexed as

acute lymphoblastic leukemiahepatitis B vaccineHLA polymorphismpediatric immune response

Identifiers

PMID41746066
PMCPMC12944832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.